LIPA, lipase A, lysosomal acid type, 3988

N. diseases: 130; N. variants: 50
Disease: Cirrhosis, Cryptogenic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0267809
Disease: Cirrhosis, Cryptogenic
Cirrhosis, Cryptogenic 		0.050 AlteredExpression disease BEFREE LAL activity < 0.265 nmol/spot/h was strongly associated with cryptogenic significant fibrosis and <0.235 nmol/spot/h with cryptogenic cirrhosis. 31113613 2020
CUI: C0267809
Disease: Cirrhosis, Cryptogenic
Cirrhosis, Cryptogenic 		0.050 AlteredExpression disease BEFREE The prevalence of CC decreased across the tertiles of LAL activity: 22.2% in the lowest, 4.6% in the intermediate and 0.5% in the highest tertile. 31392821 2019
CUI: C0267809
Disease: Cirrhosis, Cryptogenic
Cirrhosis, Cryptogenic 		0.050 AlteredExpression disease BEFREE Among cirrhosis of different etiologies, those with cryptogenic cirrhosis show the most significant reductions of LAL activity. 31435171 2019
CUI: C0267809
Disease: Cirrhosis, Cryptogenic
Cirrhosis, Cryptogenic 		0.050 AlteredExpression disease BEFREE We found a marked reduction of LAL activity in patients with cryptogenic cirrhosis compared to the other known aetiologies. 28396038 2017
CUI: C0267809
Disease: Cirrhosis, Cryptogenic
Cirrhosis, Cryptogenic 		0.050 Biomarker disease BEFREE Lysosomal Acid Lipase Activity Is Reduced Both in Cryptogenic Cirrhosis and in Cirrhosis of Known Etiology. 27219619 2016