|
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
Malignant neoplasm of stomach
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Thus, we examined whether dietary n-3 and n-6 PUFAs are associated with the risk of gastric cancer and further investigated whether fatty acid desaturases 1 and 2 (FADS1 and FADS2) modify this association.
|
29491470 |
2018 |
|
Hypertensive disease
|
0.230 |
GeneticVariation
|
group |
BEFREE |
The association between rs174546 (T<C) and BP z-score as well as the mediating effects of selected key PUFA levels (dihomo-gamma-linolenic acid, DGLA; arachidonic acid, ARA; eicosapentaenoic acid, EPA) or estimated D5D activity (D5D index) and BMI z-score were investigated through path model analyses, adjusting for sex, age, educational level of parents, family history of hypertension, lifestyle factors and blood levels of saturated and monounsaturated fatty acids, triglycerides and low density lipoprotein cholesterol.
|
28732058 |
2017 |
|
Hypertensive disease
|
0.230 |
GeneticVariation
|
group |
BEFREE |
These findings suggest that the polymorphisms of rs174556 in the FADS1 gene are very likely to be associated with ACS in Chinese Han population, especially in subjects with hypertension.
|
23555103 |
2013 |
|
Hypertensive disease
|
0.230 |
GeneticVariation
|
group |
BEFREE |
Fatty acid desaturase 1 rs174546 (C>T) did not associate with hypertension.
|
29989339 |
2018 |
|
Obesity
|
0.220 |
GeneticVariation
|
disease |
BEFREE |
There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1.
|
21796137 |
2011 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
The FADS1 rs174547 CC variant was also associated with significantly increased CHD risk compared with the TT and TC variant (adjusted OR=1.53, 95%CI: 1.01-2.31), and the effect was more evident among nonsmokers and females.
|
22490578 |
2012 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Dietary n-3 polyunsaturated fatty acid intakes modify the effect of genetic variation in fatty acid desaturase 1 on coronary artery disease.
|
25849351 |
2015 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.
|
27004414 |
2016 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Human genetic variants near the FADS (fatty acid desaturase) gene cluster (<i>FADS1-2</i>-<i>3</i>) are strongly associated with cardiometabolic traits including dyslipidemia, fatty liver, type 2 diabetes mellitus, and coronary artery disease.
|
29074585 |
2018 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Fatty acid profile in plasma cholesteryl esters and FADS1 genotype at baseline were measured in a random subcohort (n = 1323) and incident CHD cases (n = 537).
|
22911844 |
2012 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Malignant Neoplasms
|
0.140 |
GeneticVariation
|
group |
BEFREE |
Genes coding for the fatty acid desaturases (FADS1, 2, 3) localized at the cancer genomic hotspot 11q13 locus are required for the biosynthesis of 20 carbon polyunsaturated fatty acids (PUFA) that are direct eicosanoid precursors.
|
22140540 |
2011 |
|
Malignant Neoplasms
|
0.140 |
GeneticVariation
|
group |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Malignant Neoplasms
|
0.140 |
GeneticVariation
|
group |
BEFREE |
Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.
|
20691134 |
2010 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Genes subject to cis-eQTL effects that were common to both CD4+ and B lymphocytes at RA risk loci were FADS1, FADS2, BLK, FCRL3, ORMDL3, PPIL3, and GSDMB.
|
29193869 |
2018 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Asthma
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we evaluated the influence of the FADS1 FADS2 gene cluster polymorphisms on the association between BF and asthma.
|
21933193 |
2012 |
|
Asthma
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
Bipolar Disorder
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population.
|
30531795 |
2018 |
|
Bipolar Disorder
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder.
|
28115744 |
2018 |