|
Malignant neoplasm of stomach
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Thus, we examined whether dietary n-3 and n-6 PUFAs are associated with the risk of gastric cancer and further investigated whether fatty acid desaturases 1 and 2 (FADS1 and FADS2) modify this association.
|
29491470 |
2018 |
|
Schizophrenia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Here we determined Delta5 desaturase (FADS1), Delta6 desaturase (FADS2), elongase (HELO1 [ELOVL5]), peroxisomal (PEX19), and Delta9 desaturase (stearoyl-CoA desaturase, SCD) mRNA expression, and relevant fatty acid product:precursor ratios as estimates of enzyme activities, in the postmortem prefrontal cortex (PFC) of patients with SZ (n=20) and non-psychiatric controls (n=20).
|
19195843 |
2009 |
|
Hypertensive disease
|
0.230 |
GeneticVariation
|
group |
BEFREE |
The association between rs174546 (T<C) and BP z-score as well as the mediating effects of selected key PUFA levels (dihomo-gamma-linolenic acid, DGLA; arachidonic acid, ARA; eicosapentaenoic acid, EPA) or estimated D5D activity (D5D index) and BMI z-score were investigated through path model analyses, adjusting for sex, age, educational level of parents, family history of hypertension, lifestyle factors and blood levels of saturated and monounsaturated fatty acids, triglycerides and low density lipoprotein cholesterol.
|
28732058 |
2017 |
|
Hypertensive disease
|
0.230 |
GeneticVariation
|
group |
BEFREE |
These findings suggest that the polymorphisms of rs174556 in the FADS1 gene are very likely to be associated with ACS in Chinese Han population, especially in subjects with hypertension.
|
23555103 |
2013 |
|
Hypertensive disease
|
0.230 |
GeneticVariation
|
group |
BEFREE |
Fatty acid desaturase 1 rs174546 (C>T) did not associate with hypertension.
|
29989339 |
2018 |
|
Obesity
|
0.220 |
Biomarker
|
disease |
BEFREE |
A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice.
|
27832159 |
2016 |
|
Obesity
|
0.220 |
GeneticVariation
|
disease |
BEFREE |
There is evidence that obesity and obesity-related phenotypes are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1.
|
21796137 |
2011 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
The FADS1 rs174547 CC variant was also associated with significantly increased CHD risk compared with the TT and TC variant (adjusted OR=1.53, 95%CI: 1.01-2.31), and the effect was more evident among nonsmokers and females.
|
22490578 |
2012 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Dietary n-3 polyunsaturated fatty acid intakes modify the effect of genetic variation in fatty acid desaturase 1 on coronary artery disease.
|
25849351 |
2015 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.
|
27004414 |
2016 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Human genetic variants near the FADS (fatty acid desaturase) gene cluster (<i>FADS1-2</i>-<i>3</i>) are strongly associated with cardiometabolic traits including dyslipidemia, fatty liver, type 2 diabetes mellitus, and coronary artery disease.
|
29074585 |
2018 |
|
Coronary heart disease
|
0.160 |
GeneticVariation
|
disease |
BEFREE |
Fatty acid profile in plasma cholesteryl esters and FADS1 genotype at baseline were measured in a random subcohort (n = 1323) and incident CHD cases (n = 537).
|
22911844 |
2012 |
|
Coronary heart disease
|
0.160 |
AlteredExpression
|
disease |
BEFREE |
Delta-5 and delta-6 desaturases, FADS1 and FADS2, respectively, influence the serum, plasma and membrane phospholipid levels of LA, ALA and long-chain polyunsaturated fatty acids during pregnancy, lactation, and may influence an infant's IQ, atopy and coronary heart disease (CHD) risk.
|
20558833 |
2010 |
|
Malignant Neoplasms
|
0.140 |
GeneticVariation
|
group |
BEFREE |
Genes coding for the fatty acid desaturases (FADS1, 2, 3) localized at the cancer genomic hotspot 11q13 locus are required for the biosynthesis of 20 carbon polyunsaturated fatty acids (PUFA) that are direct eicosanoid precursors.
|
22140540 |
2011 |
|
Malignant Neoplasms
|
0.140 |
AlteredExpression
|
group |
BEFREE |
We thus hypothesize that the commonly overexpressed COX in cancer (~90% of colon cancer patients) can be taken advantage to suppress cell growth by knocking down delta-5-desaturase (D5D, a key enzyme that converts DGLA to arachidonic acid).
|
27101738 |
2016 |
|
Malignant Neoplasms
|
0.140 |
GeneticVariation
|
group |
BEFREE |
Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.
|
20691134 |
2010 |
|
Malignant Neoplasms
|
0.140 |
Biomarker
|
group |
BEFREE |
Since histone deacetylase inhibitors have been well-known to suppress cancer cell migration and invasion, we thus tested whether knockdown of delta-5-desaturase and DGLA treatment could also be used to inhibit cancer migration and invasion of colon cancer and pancreatic cancer cells.
|
28157665 |
2017 |
|
Rheumatoid Arthritis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Genes subject to cis-eQTL effects that were common to both CD4+ and B lymphocytes at RA risk loci were FADS1, FADS2, BLK, FCRL3, ORMDL3, PPIL3, and GSDMB.
|
29193869 |
2018 |
|
Asthma
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we evaluated the influence of the FADS1 FADS2 gene cluster polymorphisms on the association between BF and asthma.
|
21933193 |
2012 |
|
Bipolar Disorder
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population.
|
30531795 |
2018 |
|
Laryngeal Squamous Cell Carcinoma
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
The fatty acid desaturase 1 (FADS1) gene variant is a novel susceptibility marker for laryngeal squamous cell carcinoma identified by a recent genome-wide association study, but it is still unclear whether this genetic variant continues to influence oral cancer recurrence or death.
|
27542551 |
2017 |
|
Coronary Artery Disease
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Human genetic variants near the FADS (fatty acid desaturase) gene cluster (<i>FADS1-2</i>-<i>3</i>) are strongly associated with cardiometabolic traits including dyslipidemia, fatty liver, type 2 diabetes mellitus, and coronary artery disease.
|
29074585 |
2018 |
|
Coronary Artery Disease
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Fatty acid desaturase 1 polymorphisms are associated with coronary heart disease in a Chinese population.
|
22490578 |
2012 |
|
Coronary Artery Disease
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The present study suggests that the FADS1 rs174546 SNP and the FADS2 rs174601 SNP are associated with the risk of CAD and IS, and are likely to influence serum lipid levels.
|
26261632 |
2015 |
|
Coronary Artery Disease
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.
|
27004414 |
2016 |