FADS1, fatty acid desaturase 1, 3992

N. diseases: 125; N. variants: 32
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.020 GeneticVariation disease BEFREE Lack of association of SNPs from the FADS1-FADS2 gene cluster with major depression or suicidal behavior. 26513616 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.020 AlteredExpression disease BEFREE After correcting for multiple comparisons, FADS1 mRNA expression was significantly lower in MDD patients relative to controls (-27%, p=0.009), and there were trends for lower expression of FADS2 (-30%, p=0.07), HELO1 (-37%, p=0.02), and SCD (-43%, p=0.02). 20863572 2011