Disease: Parkinson Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 AlteredExpression disease BEFREE Strikingly, inactivation of Lmx1a and Lmx1b recreates cellular features observed in Parkinson's disease. 27407143 2016
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 AlteredExpression disease BEFREE Notably, LMX1B expression was lower in brain tissue affected by Parkinson's disease. 26526610 2015
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 Biomarker disease BEFREE Thus, these results reveal a sustained and essential requirement of Lmx1b for the function of midbrain mDA neurons and suggest that its dysfunction is associated with Parkinson's disease pathogenesis. 25915474 2015
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 Biomarker disease BEFREE Lmx1b can promote the differentiation of embryonic stem cells to dopaminergic neurons associated with Parkinson's disease. 22426839 2012
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 GeneticVariation disease BEFREE Three SNPs in LMX1A and one in LMX1B were associated with PD. 19189040 2009
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.060 Biomarker disease BEFREE These include factors regulating dopaminergic neurogenesis (Nurr 1, Ptx-3, and Lmx1b) and related proteins, together with genes involved in familial Parkinson's disease (alpha synuclein, parkin, and ubiquitin carboxy terminal hydroxylase L1), and endogenous and environmental agents. 11724911 2001