|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
Racial (black-white) differences in serum lipoprotein (a) distribution and its relation to parental myocardial infarction in children. Bogalusa Heart Study.
|
1829398 |
1991 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein Lp(a). A risk factor for myocardial infarction.
|
2969235 |
1988 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein (a) [Lp(a)] phenotypes of 69 myocardial infarction survivor and 56 stroke patients were reported and compared to those of 190 healthy Chinese.
|
8194380 |
1994 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
High lipoprotein(a) in children from kindreds with parental premature myocardial infarction.
|
8284108 |
1993 |
|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
To compare lipoprotein(a) levels in diabetic patients and normoglycemic relatives in familial NIDDM and to assess whether Lp(a) is a risk factor for myocardial infarction in this population.
|
8495614 |
1993 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Comparative analysis of apo(a) gene alleles: distribution of pentanucleotide repeats in position -1373 and C/T transition in position +93 among patients with myocardial infarction and a control group in St. Petersburg, Russia.
|
9259986 |
1997 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a) and the significance of the association between platelet glycoprotein IIIa polymorphisms and the risk of premature myocardial infarction.
|
9733226 |
1998 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Sequence polymorphisms in the apolipoprotein(a) gene and their association with lipoprotein(a) levels and myocardial infarction. The ECTIM Study.
|
10407493 |
1999 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The CD14 CC genotype was associated with incidence of new coronary occlusion (P=0.026); TNF-alpha AA genotype with history of myocardial infarction (MI, P=0.04), and A allele with total occlusions at baseline (P=0.027), and systolic blood pressure (P=0.046); and IL-6-174 CC genotype with baseline minimum lumen diameter (P=0.043) and reduction in lipoprotein(a) with fluvastatin (P=0.03).
|
11199329 |
2000 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
APO(a) variants and lipoprotein(a) in men with or without myocardial infarction.
|
12127051 |
2002 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms of the apolipoprotein(a) gene with lipoprotein(a) levels and myocardial infarction.
|
12578871 |
2003 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to analyze, on a double-blind basis, the relationships between the apolipoprotein(a) (apo(a)) gene and protein size polymorphisms in healthy volunteers (n = 99) and patients with premature myocardial infarction (n = 91).
|
14580163 |
2003 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The apo(a) [apolipoprotein(a)] gene is responsible for variations in plasma lipoprotein(a), high levels of which are a risk factor for atherosclerosis and myocardial infarction.
|
14680477 |
2004 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We tested the hypothesis that apolipoprotein(a) pentanucleotide repeat genotype predicts elevated lipoprotein(a) levels and risk of myocardial infarction (MI) and ischemic heart disease (IHD) in the general population.
|
18682504 |
2008 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Finally, we tested these 24 SNPs in a third study (475 cases and 619 controls) and found that 5 SNPs in 4 genes (ENO1, FXN (2 SNPs), HLA-DPB2, and LPA) were associated with MI in the third study (1-sided P<0.05), and had the same risk alleles in all three studies.
|
18682748 |
2008 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In healthy blood donors and in patients with CAD complicated by myocardial infarction (MI) four apolipoprotein gene polymorphisms [APO (a) PNR, APO E, APO CI and APO CII] were determined and plasma levels of total homocysteine, total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HLD-C) and apolipoproteins (apo A-I, Apo B, Apo E) were measured.
|
19014618 |
2008 |
|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In the CCHS, multivariable-adjusted hazard ratios (HRs) for MI for elevated lipoprotein(a) levels were 1.2 (95% confidence interval [CI], 0.9-1.6; events/10,000 person-years, 59) for levels between the 22nd and 66th percentile, 1.6 (95% CI, 1.1-2.2; events/10,000 person-years, 75) for the 67th to 89th percentile, 1.9 (95% CI, 1.2-3.0; events/10,000 person-years, 84) for the 90th to 95th percentile, and 2.6 (95% CI, 1.6-4.1; events/10,000 person-years, 108) for levels greater than the 95th percentile, respectively, vs levels less than the 22nd percentile (events/10,000 person-years, 55) (trend P < .001).
|
19509380 |
2009 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The association of LPA KIV-2 genotypes raising plasma levels of lipoprotein(a) with increased risk of myocardial infarction strongly supports a causal association of lipoprotein(a) with risk of myocardial infarction.
|
21231777 |
2011 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a) (Lp(a)) is an important causal cardiovascular risk factor, with serum Lp(a) levels predicting atherosclerotic heart disease and genetic determinants of Lp(a) levels showing association with myocardial infarction.
|
21283670 |
2011 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) concentration does not differ between sexes in healthy offspring of patients with premature myocardial infarction.
|
21519277 |
2011 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lp(a) and LPA kringle IV type 2 tertiles also associated with the risk of myocardial infarction in general population studies (trend: P<0.001 to 0.003).
|
22516069 |
2012 |
|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
As some incorrect reclassification of individuals with no events occurred, addition of lipoprotein(a) levels ≥80th percentile overall yielded net reclassification indices of +16% (95% confidence interval: 8% to 24%) and +3% (-1% to 8%) for MI and CHD, respectively.
|
23375930 |
2013 |
|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of lipoprotein(a) were not causally associated with increased low-grade inflammation as measured through CRP despite a causal association with increased risk of aortic valve stenosis and MI.
|
25938632 |
2015 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Elevated lipoprotein(a) levels represent a genetically determined risk factor for myocardial infarction (MI) and aortic valve stenosis (AVS).
|
26656145 |
2016 |