LPA, lipoprotein(a), 4018

N. diseases: 340; N. variants: 49
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE No apparent association between the VNTR genotype and plasma lipid concentration was observed; however, for the same genotype, the CAD and stroke patients frequently showed higher lipoprotein(a) and lower HDL cholesterol concentrations than the control group. 8665685 1996
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Multiple regression analyses for all subjects (n=90) showed that being a stroke patient (p<0.0001), fibrinogen (p<0.0001) and lipoprotein(a) (p=0.0075) were independent predictors of clot permeability (model R2 0.79). 19942259 2010
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE The comparable strength of associations of the LPA score with coronary disease and peripheral vascular disease but not with stroke suggest that lipoprotein(a) may have effects on atherothrombotic vascular disease that are only relevant at specific sites. 21252144 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Levels of LDL corrected for lipoprotein(a) were an even stronger predictor of dementia with stroke in the adjusted multivariate analysis. 10422994 1999
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE We report apolipoprotein(a) (apo(a)) phenotypes of 69 myocardial infarction survivors and 56 stroke patients, and compare them with those of 190 healthy Chinese. 8187226 1994
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Antisense oligonucleotide therapy has shown some promise in treating stroke causes that are genetically determined and resistant to classic prevention approaches such as elevated lipoprotein (a) and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). 30635869 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Lipoprotein (a) and stroke. 10961170 2000
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Lipoprotein(a) and other ASCVD risk factors were measured at baseline (1996-1998) in the biracial Atherosclerosis Risk in Communities study; participants without prevalent ASCVD (coronary heart disease or stroke) were monitored ∼15 years for incident ASCVD events. 30685442 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE In this cross-sectional study we compared the abilities of lipoprotein(a) [Lp(a)], plasminogen activator inhibitor-1 (PAI-1), and tissue plasminogen activator (TPA) to discriminate between individuals with and without a history of stroke from among subjects in a metabolic ward. 8548412 1996
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Valproic acid can increase lipoprotein(a) and decrease fibrinogen, which may increase the risk of stroke or other thrombotic events. 19135623 2009
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Various prothrombotic risk factors have been investigated in pediatric stroke including elevated homocysteine and lipoprotein (a), antithrombin, protein C and protein S deficiency, Factor V Leiden, Factor II G20210A and plasminogen activator inhibitor-1 4G/5G polymorphism. 23092062 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE High plasma concentrations of lipoprotein(a) [Lp(a), which is encoded by the APOA gene] increase an individual's risk of developing diseases, such as coronary artery diseases, restenosis, and stroke. 21804189 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE High concentrations of plasma lipoprotein(a) [Lp(a)] have been inferred to be an independent risk factor for cardiovascular and cerebrovascular diseases, such as coronary artery diseases, restenosis, and stroke. 29064597 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Most children with pediatric stroke have more than one risk factor, mainly vasculopathies or elevation of lipoprotein(a). 17675027 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Lipoprotein(a) [Lp(a)] is an established risk factor for coronary disease and stroke, but mechanisms underlying this association are unknown. 21078622 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Lipoprotein(a) Lp(a) is a cholesterol-rich, LDL-like particle that is independently associated with an increased risk for ischemic heart disease, atherosclerosis, thrombosis, and stroke. 28608522 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE In 269 primary schoolchildren aged 6-11 years (145 boys and 124 girls) we measured the blood concentrations of total cholesterol, apolipoproteins B and A-1, and lipoprotein(a), and questioned their parents about coronary or cerebral vascular events. 9133253 1997
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Serum lipoprotein(a) and risk of hemorrhagic stroke among incident peritoneal dialysis patients: a large study from a single center in China. 31498021 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Elevated lipoprotein (a) [LP (a)] concentrations are independent risk factors of coronary heart disease or stroke in young adults. 9164807 1997
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 AlteredExpression group BEFREE Higher prevalences of hypertension, diabetes, obesity (in women), elevated lipoprotein(a) level, smoking (in men), and low socioeconomic status may contribute to the higher stroke incidence and mortality in US Blacks as compared with Whites. 10604768 1999
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Increased levels of lipoprotein(a) (Lp[a])are known independent risk factor for atherosclerosis, heart disease, and stroke in adults. 22187404 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Previous studies have examined the association of lipoprotein(a) and risk of stroke; however, the results are conflicting. 31272552 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE One hundred forty-eight Caucasian infants and children (aged 0.5 to 16 years) with stroke and 296 age-matched controls from the same geographic areas as the patients were analyzed for increased lipoprotein (a) [Lp(a)] levels >30 mg/dL; for the presence of the factor V (FV) G1691A mutation, the prothrombin (PT) G20210A variant, and the TT677 genotype of methylenetetrahydrofolate reductase (MTHFR); and deficiencies of protein C, protein S, and antithrombin. 10572079 1999
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 Biomarker group BEFREE Raised lipoprotein (a), protein C deficiency, and stroke of vascular origin are risk factors for recurrent arterial ischaemic stroke in childhood. 12443591 2002
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.500 GeneticVariation group BEFREE Serum lipoprotein (a) is associated with increased risk of stroke in Chinese adults: A prospective study. 31437611 2019