|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
A modified algorithm with lipoprotein(a) added for diagnosis of familial hypercholesterolemia.
|
31436336 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Low-density lipoprotein cholesterol (LDL-C) level and lipoprotein(a) [Lp(a)] ≥ 50 mg/dL predict atherosclerotic cardiovascular disease (ASCVD) risk in adults with familial hypercholesterolemia (FH), but their role for children with FH is less clear.
|
30150142 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) [Lp(a)] increases CAD in FH, although the independence of this association relative to other CAD risk factors remains unclear.
|
26340131 |
2015 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of the present study is to compare the predictive value of an LPA variant, rs10455872, as well as Lp(a) concentration on the prevalence of CVD and on the age of the first CVD event in a cohort of genetically confirmed heterozygous patients with familial hypercholesterolemia (FH).
|
31103339 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An investigation of the influence of selected factors on the clinical expression of the FH Afrikaner-1 mutation in this family indicated that it was especially the elevated apolipoprotein (a) levels, in addition to low levels of high density lipoprotein cholesterol and raised triglyceride and apolipoprotein B levels, that were associated with a greater risk of developing CHD.
|
8370148 |
1993 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
to analyze the relationship between lipid disturbance, including lipoprotein(a) (Lp(a)) levels, and development of ischemic heart disease (IHD) in patients with familial hypercholesterolemia (FH).
|
29096862 |
2017 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study's aim was to determine whether biochemical risk factors such as lipoprotein(a), fibrinogen, homocysteine, and insulin, as well as low-density lipoprotein (LDL) particle size, were predictive of carotid intimamedia thickness (IMT), an early marker of atherosclerosis, in subjects with familial hypercholesterolemia (FH).
|
10235090 |
1999 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The substantial acute reduction of lipoprotein (a) (means: 65%, heterozygous FH; 68%, homozygous FH) has not been reported with other therapies.
|
1414897 |
1992 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
The phenotypic diversity of familial hypercholesterolemia (FH) and lipoprotein(a) hyperlipidemia (Lp(a)-HLP), as defined risks for coronary artery disease with genetic background, and their frequent co-incidence with additional cardiovascular risk factors require a critical revisiting of the current diagnostic and screening criteria as well as therapeutic recommendations established for FH or isolated Lp(a)-HLP, since there is no clear guidance for patient stratification and disease management for combined cases.
|
20129380 |
2009 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Familial hypercholesterolemia (FH) and elevated lipoprotein(a) [Lp(a)] are inherited disorders associated with premature atherosclerotic cardiovascular disease (ASCVD).
|
30846097 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the associations of lipoprotein (a) [Lp(a)] with the FH phenotype, genotype and roles of Lp(a) in determining CAD risk among patients with and without FH.
|
28351002 |
2017 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic traits for familial hypercholesterolemia and high lipoprotein(a) concentrations apparently co-exist and are associated with a higher ASVCD risk than each alone.
|
31393421 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The short-term effects of low-density lipoprotein (LDL) apheresis using a dextran sulfate-cellulose (DSC) column equipped with a plasma separator using a polysulfone (PS) membrane filter on the serum total cholesterol, lipoprotein(a) (Lp(a)), C4b binding protein (C4bp), protein C and protein S and complement components levels were examined in a patient with familial hypercholesterolemia (heterozygote, type IIa).
|
9222877 |
1994 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of the Pro664-Leu mutation in the low-density lipoprotein receptor and its relation to lipoprotein(a) levels in patients with familial hypercholesterolemia of Dutch ancestry from The Netherlands and Canada.
|
1493640 |
1992 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess the relationship between LDLR genotype and the plasma levels of PCSK9, LDL-C, and lipoprotein (a) (Lp(a)) in a large cohort of genetically defined FH heterozygotes (HeFH).
|
26371983 |
2015 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, when adjusting LDL cholesterol for lipoprotein(a) cholesterol content the corresponding values were 24 mg/dL for individuals unlikely to have familial hypercholesterolaemia, 22 mg/dL for those with possible familial hypercholesterolaemia, and 21 mg/dL for those with probable or definite familial hypercholesterolaemia (ptrend=0·46).
|
27185354 |
2016 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study confirmed that the MFHS is a strong predictor of prevalent CVD in FH and that the addition of lipoprotein(a) offers a minor improvement in the discrimination of the score.
|
28801029 |
2018 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) concentration is associated with plasma arachidonic acid in subjects with familial hypercholesterolaemia.
|
31262370 |
2019 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of lipoprotein (a) in children with familial hypercholesterolemia.
|
8197753 |
1994 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent literature involving CNVs and dyslipidemias has focused mainly on rare CNVs causing familial hypercholesterolemia, and a common CNV polymorphism as the major determinant of lipoprotein(a) plasma concentrations.
|
29303791 |
2018 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Elevated lipoprotein(a) levels contribute to the occurrence and severity of early-onset coronary disease and add to the already enhanced risk in patients with familial hypercholesterolaemia.
|
12889664 |
2003 |
|
Hypercholesterolemia, Familial
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Segregation analysis of plasma lipoprotein(a) levels in pedigrees with molecularly defined familial hypercholesterolemia.
|
7607414 |
1995 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Phase 2 and 3 clinical trials in patients with moderate and severe hypercholesterolemia (including FH) show that this approach is safe and highly efficacious to lower LDL-C and lipoprotein(a).
|
25248569 |
2014 |
|
Hypercholesterolemia, Familial
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated lipoprotein(a) and familial hypercholesterolemia in the coronary care unit: Between Scylla and Charybdis.
|
29480541 |
2018 |
|
Hypercholesterolemia, Familial
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein(a) polymorphism predicts the increase of Lp(a) by pravastatin in patients with familial hypercholesterolaemia treated with bile acid sequestration.
|
8500516 |
1993 |