|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review will focus on LPA and S1P, two bioactive lipid mediators in their regulation of angiogenesis and cell migration that are critical for tumor growth and spread.
|
30048709 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the characteristics of the vasculature vary by organ and tumor types, and how drug delivery and leukocyte trafficking are affected by modification of vascular function by LPA in different cancers is unclear.
|
30301839 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, the pharmacological antagonist of LPA receptors significantly reduced the lymphatic vessel density in tumor and lymph node metastasis in tumor-bearing nude mice.
|
30053596 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor associated endothelial cells (TAECs) exposed to LPA demonstrated sustained nuclear PKD-1 phosphorylation, and elevated mRNA levels of ephrin B2, and reduced mRNA expression of CD36.
|
28186980 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Univariate analysis showed that age (P < 0.001), BMI (P < 0.01), cholesterol (P < 0.001), high-density lipoprotein (P < 0.001), apolipoprotein A (P < 0.01), history of tumor (P < 0.05), visual analogue scale (VAS) pain score (P < 0.001), and operative duration (P < 0.05) were significant risk factors for DVT.
|
27388282 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Lipoprotein(a) and vitamin C impair development of breast cancer tumors in Lp(a)+; Gulo-/- mice.
|
27573077 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that tumor and stromal LPA receptors, in particular LPA1 and LPA5, play different roles in invasion and the seeding of metastasis.
|
25158955 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The S1P and LPA receptors are differentially expressed on tumor cell lines in vitro.
|
20480410 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of LPA receptors in tumor growth, ascites formation, and cytokine production was assessed in a mouse xenograft model.All statistical tests were two-sided.
|
19001604 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of human apolipoprotein(a) kringles in colon cancer cells suppresses angiogenesis-dependent tumor growth and peritoneal dissemination.
|
15517541 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The expression pattern and functions of these LPA receptors in various tumors have not been fully examined, except in ovarian cancer.
|
15220934 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Inhibition of angiogenesis and angiogenesis-dependent tumor growth by the cryptic kringle fragments of human apolipoprotein(a).
|
12746434 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CHO cells secreting a truncated apo(a) protein with only six kringle 4 repeats did not exhibit delayed tumor growth nor did it impair angiogenesis.
|
10208849 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We examined Apo A-I mRNA expression in peripheral blood samples from 4 healthy donors, 20 colon carcinoma patients, and 11 individuals with tumor disease other than colon cancer.
|
9683776 |
1998 |