The LPLS447X polymorphism is significantly associated with subclinical cerebral infarction and incident clinical ischemic stroke in men from a middle-aged American population.
Patients with ischemic stroke have a lower frequency of the LPLSer447Ter mutation, which indicates that this mutation may have protective effect on ischemic stroke.
Cholesteryl ester transfer protein TaqI B and lipoprotein lipaseSer447Ter gene polymorphisms are not associated with ischaemic stroke in Greek patients.
In the present work, we report results of case-control study of IS association with apolipoprotein E gene (APOE) (promoter and coding polymorphisms) and lipoprotein lipase gene (LPL) (presence/absence of a HindIII cutting site).
This meta-analysis indicated that LPLSer447Ter polymorphism was associated with a significant reduction in the risk of ischemic stroke, especially atherosclerotic stroke subtype in both Caucasian and East-Asian.
The present study was carried out with an aim to evaluate the association between the genetic variants of lipoprotein lipase gene [HindIII (+/+)/HindIII (-/-)], multiple drug resistance gene (C3435T) and endothelial nitric oxide synthase gene (4a/4b) with clinical outcome including an increased risk of recurrent stroke or death in ischemic stroke patients on atorvastatin therapy.