The present study was carried out with an aim to evaluate the association between the genetic variants of lipoprotein lipase gene [HindIII (+/+)/HindIII (-/-)], multiple drug resistance gene (C3435T) and endothelial nitric oxide synthase gene (4a/4b) with clinical outcome including an increased risk of recurrent stroke or death in ischemic stroke patients on atorvastatin therapy.
This meta-analysis indicated that LPLSer447Ter polymorphism was associated with a significant reduction in the risk of ischemic stroke, especially atherosclerotic stroke subtype in both Caucasian and East-Asian.
In the present work, we report results of case-control study of IS association with apolipoprotein E gene (APOE) (promoter and coding polymorphisms) and lipoprotein lipase gene (LPL) (presence/absence of a HindIII cutting site).
Cholesteryl ester transfer protein TaqI B and lipoprotein lipaseSer447Ter gene polymorphisms are not associated with ischaemic stroke in Greek patients.
Patients with ischemic stroke have a lower frequency of the LPLSer447Ter mutation, which indicates that this mutation may have protective effect on ischemic stroke.
The LPLS447X polymorphism is significantly associated with subclinical cerebral infarction and incident clinical ischemic stroke in men from a middle-aged American population.