Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, nobiletin may alleviate lipid accumulation and secretion of pro-inflammatory cytokines by enhancing the inhibitory effect of miR-590 on LPL expression, suggesting a promising strategy for potential drug development for atherosclerosis.
|
30471854 |
2019 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Krüppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo.
|
31518965 |
2019 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using Hematoxylin-eosin (H&E) and Oil Red O staining, we found that CCDC80 overexpression in vivo significantly increased plasma lipid contents, decreased the expression and activity of lipoprotein lipase (LPL), and accelerated the development of atherosclerosis.
|
30439364 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-27 prevents atherosclerosis by inhibiting inflammatory responses induced by lipoprotein lipase.
|
31169351 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, muscle and macrophage LpL have opposite effects on atherosclerosis.
|
29419410 |
2018 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphism (SNP) in lipoprotein lipase (LPL) gene (rs1801177) is strongly associated with the increased progression of atherosclerosis, threatening global public health.
|
29175215 |
2018 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
VLDL remnants have been shown as the major atherogenic lipoproteins in postprandial plasma associated with LPL activity as the targets for prevention of atherosclerosis.
|
29493553 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that LPL gene plays a major role in extreme HTG associated with hyperchylomicronemia, although the condition may not cause severe atherosclerosis.
|
29153744 |
2018 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We showed that VLDL remnants are the major atherogenic lipoproteins in the postprandial plasma associated with insufficient LPL activity and a causal factor in the initiation and progression of atherosclerosis.
|
29307667 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of LPL in atherosclerosis is still controversial as reported in the literature.
|
29453968 |
2018 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hyperlipidemia is a risk factor of arteriosclerosis, stroke, and other coronary heart disease, which has been shown to correlate with single nucleotide polymorphisms of genes essential for lipid metabolism, such as lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5).
|
29425239 |
2018 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It is concluded that miR-377 upregulates GPIHBP1 expression, increases the LPL binding to GPIHBP1, and reduces plasma triglyceride levels, likely through targeting DNMT1, inhibiting atherosclerosis in ApoE-KO mice.
|
30232292 |
2018 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have shown that miR-467b plays a central role in the progression of atherosclerosis via regulating LPL expression.
|
27678191 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous researches have indicated that macrophage-derived lipoprotein lipase (LPL) promotes atherosclerosis progression by accelerating lipid accumulation and pro-inflammatory cytokine secretion.
|
28444107 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Macrophage lipoprotein lipase (LPL) induces lipid accumulation and promotes atherosclerosis.
|
28205069 |
2017 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lipoprotein lipase (LPL) expressed in macrophages plays an important role in promoting the development of atherosclerosis or atherogenesis.
|
28855441 |
2017 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Postprandial lipemia and lipoprotein lipase (LPL) activity play crucial roles in the pathogenesis of accelerated atherosclerosis.
|
28814963 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effects on changes of LPL and EL mass differed depending on the lipid-lowering therapy, which may impact the prevention of atherosclerosis differently.
|
27039080 |
2016 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, it has not been fully understood whether miR-27 affects the expression of LPL and subsequent development of atherosclerosis in apolipoprotein E knockout (apoE KO) mice.
|
27257686 |
2016 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
LPL with different distributions may exert distinct functions and have diverse roles in human health and disease with close association with atherosclerosis.
|
25463094 |
2014 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, macrophage LPL was reported to promote foam cell formation and atherosclerosis in vivo.
|
22772754 |
2012 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A 60-y-old chylomicronemia patient homozygous for missense mutation (G188E) in the lipoprotein lipase gene showed no accelerated atherosclerosis.
|
17854791 |
2008 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The data show that transgenic hLPL(S447X) on top of endogenous murine LPL reduces fasting TG levels in plasma but has no effect on atherosclerosis in LDLr-/- mice.
|
17087965 |
2007 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, transgenic mice expressing catalytically active or inactive LPL developed the same extent of atherosclerosis.
|
17761930 |
2007 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein lipase S447X polymorphism has been shown to be protective against atherosclerosis.
|
17662793 |
2007 |