|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We speculated that the mutation D151N in LPL gene might be associated with FCHL and early-onset coronary heart disease in this family.
|
31599081 |
2020 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
We then selected four candidate biomarkers and found that lipoprotein lipase (LPL), bone morphogenetic protein 7 and somatostatin concentrations could indicate CAD diagnosis.
|
30958112 |
2019 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several polymorphisms in the lipoprotein lipase locus have been described and are associated with variations in the activity of this enzyme, producing high concentrations of triglycerides and increased risk of CAD.
|
31227920 |
2019 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls.
|
28705542 |
2019 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, no statistically significant association was found between genetic polymorphisms of PSRC1 A>G, LPL S447X and LPA C>T and CAD.
|
30902787 |
2019 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease.
|
30694319 |
2019 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Serum EL and HL concentrations were both significantly increased in patients with CAD or in-stent restenosis, whereas serum LPL concentration was reduced significantly in patients with CAD.
|
30651409 |
2019 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Hyperlipidemia is a risk factor of arteriosclerosis, stroke, and other coronary heart disease, which has been shown to correlate with single nucleotide polymorphisms of genes essential for lipid metabolism, such as lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5).
|
29425239 |
2018 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The LPL polymorphism contributed to the severity of coronary disease in patients with MS and recent ACS.
|
29412239 |
2018 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In summary, our meta-analysis indicated that the <i>LPL</i> D9N polymorphism was associated with an increased risk of CAD, whereas the S447X and HindIII polymorphisms showed protective effects.
|
29459423 |
2018 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The role of plasma lipoprotein lipase, hepatic lipase and GPIHBP1 in the metabolism of remnant lipoproteins and small dense LDL in patients with coronary artery disease.
|
29174344 |
2018 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To investigate the independent and combined associations of genetically determined differences in LPL-mediated lipolysis and low-density lipoprotein cholesterol (LDL-C) metabolism with risk of coronary disease and diabetes.
|
30326043 |
2018 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A statistically significant increase in the risk of CAD was associated with LPL HindIII polymorphism.
|
28275220 |
2017 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD.
|
29083408 |
2017 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The objective of the current study was to investigate the effect of four such single nucleotide polymorphism (SNPs) in the genes for Lipoprotein Lipase (LPL) (rs328, rs1801177), Apolipoprotein A5 (APOA5) (rs66279) and Cholesteryl ester transfer protein (CETP) (rs708272) on HDL-C and TG levels and to examine the association of these SNPs with CAD risk.
|
28143480 |
2017 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
In a cross-sectional study, LPL was sequenced in 10 CAD case-control cohorts of the multinational Myocardial Infarction Genetics Consortium and a nested CAD case-control cohort of the Geisinger Health System DiscovEHR cohort between 2010 and 2015.
|
28267856 |
2017 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
TG and RLP-TG together with other lipids, lipoproteins and lipoprotein lipase (LPL) in both fasting and postprandial plasma were determined in generally healthy volunteers and in patients with coronary artery disease (CAD) after consuming a fat load or a more typical moderate meal.
|
27986550 |
2017 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ANGPTL4 inhibits lipoprotein lipase; we therefore searched for mutations in LPL and identified a loss-of-function variant that was associated with an increased risk of coronary artery disease (p.D36N; minor-allele frequency, 1.9%; odds ratio, 1.13; P=2.0×10(-4)) and a gain-of-function variant that was associated with protection from coronary artery disease (p.S447*; minor-allele frequency, 9.9%; odds ratio, 0.94; P=2.5×10(-7)).
|
26934567 |
2016 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Study of common variants of the apolipoprotein E and lipoprotein lipase genes in patients with coronary heart disease and variable body mass index.
|
26188224 |
2016 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The present study points to a synergistic interaction between H2H2 genotype of LPL gene and S2S2 genotype of APOC3 gene that leads to increased severity of CAD.
|
23377670 |
2013 |
|
Coronary Artery Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
There are limited data from prospective studies regarding interactions between lipoprotein lipase gene (LPL) and lifestyle factors in association with HDL-cholesterol (HDL-C) concentrations, a biomarker of coronary heart disease risk.
|
23902956 |
2013 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
|
Coronary Artery Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
LPL polymorphisms' effects on lipids and coronary artery disease are controversial among studies and populations.
|
22729917 |
2012 |