LPL, lipoprotein lipase, 4023

N. diseases: 290; N. variants: 116
Disease: Atherosclerotic lesion ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.020 Biomarker disease BEFREE Macrophage-derived lipoprotein lipase (LPL) has been shown uniformly to promote atherosclerotic lesion formation while the extent to which it affects plasma lipid and lipoprotein levels varies in wild-type and hypercholesterolemic mice. 21980507 2011
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.020 Biomarker disease BEFREE To examine the hypothesis that macrophage-derived LPL in the arterial wall enhances atherosclerotic lesion formation, we generated transgenic (Tg) rabbits that express the human LPL transgene under the control of the human scavenger receptor enhancer/promoter, which drives macrophage-specific expression of the human LPL gene. 15721013 2005