Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Tumour necrosis factor-beta polymorphism is unlikely to determine susceptibility to type 1 (insulin-dependent) diabetes mellitus.
|
1682200 |
1991 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study suggests an association between the 10.5 kb TNF-beta allele and IDDM, and demonstrates an association between monokine responses and TNF-beta genotypes.(ABSTRACT TRUNCATED AT 400 WORDS)
|
1996407 |
1991 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus.
|
8093442 |
1993 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
The segregation of these alleles has been associated with levels of TNF alpha or TNF beta production in systemic lupus erythematosis (SLE), insulin-dependent diabetes mellitus (IDDM) and in healthy control individuals.
|
9098456 |
1994 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A study of the microsatellite TNFa region close to the LTA gene showed that the presence of the TNFa1 allele in HLA-(DR3) subjects was associated with increased risk of IDDM.
|
9342542 |
1997 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TNFB gene polymorphism in insulin-dependent diabetes mellitus: association with HLA-DR alleles.
|
9587743 |
1998 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Then, we investigated AIF-1, TNF, and LT-alpha gene polymorphisms in 165 patients with type 1 diabetes, consisting of 90 patients with young-onset type 1 diabetes, 75 patients with adult-onset type 1 diabetes, and 200 control patients.
|
12559634 |
2003 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TNFA-TNFB haplotypes modify susceptibility to type I diabetes mellitus independently of HLA class II in a Moroccan population.
|
12622777 |
2003 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Initially, association with T1D was seen for LT-alpha A1069G (intron A, p=0.011, rs909253) and TNF G(-308)A (p<1x10(-5), rs1800629), but no association was observed for TNF G(-238)A (rs361525).
|
17174749 |
2006 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
The Th1 cytokines IFN-gamma and TNF-beta, secreted both spontaneously and by GAD(65)- and mitogen stimulation, were seen to a higher extent in high-risk children than in children newly diagnosed with T1D.
|
17315139 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
TNF-alpha/LTalpha T1DM-susceptible (-308G/+249G) and protective (-308G/+249A) haplotypes were identified.
|
17989340 |
2008 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The present study found an association of the TNF/LTA gene region with type 1 diabetes.
|
19167443 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of lymphotoxin alpha polymorphism with type 1 diabetes in a Tunisian population.
|
24233435 |
2014 |