|
Achalasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The rs1799724 SNP located between the lymphotoxin-α (LTA) and tumour necrosis factor-α (TNFα) genes was significantly associated with achalasia and withstood correction for testing multiple SNPs (p=1.17E-4, OR=1.41 (1.18 to 1.67)).
|
24259423 |
2014 |
|
Acquired Hypogammaglobulinemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TNF and lymphotoxin-alpha polymorphisms associated with common variable immunodeficiency: role in the pathogenesis of granulomatous disease.
|
9550427 |
1997 |
|
Acute GVH disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results provide the first report of an association between TNFA, TNFB and TNFRII polymorphic features and outcome of allo-HSCT in a Chinese population, and suggest an interaction between TNFA-857 and TNFB+252 genotypes and risk of aGVHD.
|
20548340 |
2011 |
|
Acute intermittent porphyria
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Messenger RNA levels of LTα and β were increased in pancreatic tissues from patients with AIP, compared with controls, and expression of chemokines (CXCL13, CCL19, CCL21, CCL1, and B-cell-activating factor) was increased in pancreatic and serum samples from patients.
|
22863765 |
2012 |
|
Acute intermittent porphyria
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Expression of LT α and β on acinar cells in murine pancreata Tg(Ela1-Lta,b) mice led to chronic pancreatitis and sufficed to reproduce key features of human AIP including the development of autoimmunity and AIP associated secondary extra pancreatic pathologies.
|
24508087 |
2014 |
|
Acute interstitial pneumonia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Expression of LT α and β on acinar cells in murine pancreata Tg(Ela1-Lta,b) mice led to chronic pancreatitis and sufficed to reproduce key features of human AIP including the development of autoimmunity and AIP associated secondary extra pancreatic pathologies.
|
24508087 |
2014 |
|
Acute interstitial pneumonia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Messenger RNA levels of LTα and β were increased in pancreatic tissues from patients with AIP, compared with controls, and expression of chemokines (CXCL13, CCL19, CCL21, CCL1, and B-cell-activating factor) was increased in pancreatic and serum samples from patients.
|
22863765 |
2012 |
|
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study.
|
19353239 |
2009 |
|
Acute lymphocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
For patients with ALL, the increased risk of post-HSCT relapse was associated with the donor SNP of rs213210 in the RING1 gene promoter, and the recipient SNPs of rs79327197 in the HLA-DOA gene promoter, rs2009658 in the telomeric end of lymphotoxin-alpha (LTA) gene, rs17220087 and rs17213693 in the intron of HLA-DOB gene, and rs2070120 in the 3'-UTR of HLA-DOB gene.
|
31551439 |
2019 |
|
Acute myocardial infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This observation indicates that low C4B copy number is a strong risk factor for short-term mortality after AMI in smoking Icelandic patients, whereas LTA 252 G allele is not a risk factor in Caucasian population.
|
18032375 |
2008 |
|
Acute myocardial infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
LTα C804A polymorphism was associated with an increased risk of mortality for AMI patients, although this effect was masked in patients treated with statins.
|
23398946 |
2013 |
|
Acute pancreatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TNF (TNF-308, TNFB), IL-1beta, and IL-1 receptor antagonist (IL-1RA) genotypes were determined for 190 patients with acute pancreatitis and 102 healthy volunteers.
|
11331456 |
2001 |
|
Acute respiratory distress
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
-308GA and TNFB polymorphisms in acute respiratory distress syndrome.
|
16135717 |
2005 |
|
Adenocarcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In the relationship between the histologic types and the TNF beta gene, the TNF beta 10.5/10.5-kb allele showed low frequencies: 38.5% in adenocarcinoma, 38.2% in squamous cell carcinoma, and 27.8% in small cell carcinoma, although no statistical difference was shown.
|
8313320 |
1994 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
NcoI TNF-β gene polymorphism and TNF expression are associated with an increased risk of developing Barrett's esophagus and esophageal adenocarcinoma.
|
22243485 |
2012 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
High expression of adhesion molecules/activation markers with little interleukin-2, interferon gamma, and tumor necrosis factor beta gene activation in fresh tumor-infiltrating lymphocytes from lung adenocarcinoma.
|
7641214 |
1995 |
|
Adult Classical Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We identified lymphotoxin-α (LTA) as the causative factor for autocrine and paracrine activation of canonical and noncanonical NF-κB in cHL cell lines.
|
30696620 |
2019 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that the lymphotoxin-α +252A/G gene polymorphism is a risk factor for NHL in North Americans, and this polymorphism may contribute to diffuse large B cell lymphoma susceptibility.
|
24610621 |
2014 |
|
Adult Non-Hodgkin Lymphoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium.
|
20047977 |
2010 |
|
Adult Non-Hodgkin Lymphoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The +252A/G polymorphism in the Lymphotoxin-α gene and the risk of non-Hodgkin lymphoma: a meta-analysis.
|
24610621 |
2014 |
|
Adult Non-Hodgkin Lymphoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of tumor-necrosis factor-alpha - 308 and lymphotoxin-alpha + 250: possible modulation of susceptibility to apoptosis in chronic lymphocytic leukemia and non-Hodgkin lymphoma mononuclear cells.
|
19021060 |
2008 |
|
Adult Non-Hodgkin Lymphoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor alpha-308 and Lymphotoxin alpha+252 genetic polymorphisms and the susceptibility to non-Hodgkin lymphoma in Egypt.
|
22177457 |
2012 |
|
Adult Non-Hodgkin Lymphoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Lymphotoxin alpha (LTA) polymorphism is associated with prognosis of non-Hodgkin's lymphoma in a Chinese population.
|
23840460 |
2013 |
|
Adult Non-Hodgkin Lymphoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
A haplotype comprising SNPs in two proinflammatory cytokines, tumor necrosis factor-alpha and lymphotoxin-alpha (rs1800629, rs361525, rs1799724, rs909253, and rs2239704), increased non-Hodgkin lymphoma risk overall (OR, 1.31; 95% CI, 1.06-1.63; P = 0.01) and notably for diffuse large B cell (OR, 1.64; 95% CI, 1.23-2.19; P = 0.0007).
|
17018637 |
2006 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We studied tumor necrosis factor (TNF), lymphotoxin-alpha (LT-alpha), and TNF receptors type 1 (TNFR-1) and type 2 (TNFR-2) gene polymorphisms as well as HLA class II DRB1 alleles in Japanese patients with human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy (HAM) (n = 51), patients with adult T-cell leukemia/lymphoma (ATL) (n = 48), asymptomatic HTLV-I carriers (n = 50), and HTLV-I seronegative, normal controls (n = 112).
|
11163081 |
2000 |