|
Asthma, Aspirin-Induced
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
The over-expression of the LTC(4) synthase in a mouse asthma model also replicates the key features of AIA.
|
21429049 |
2011 |
|
Asthma, Aspirin-Induced
|
0.340 |
Biomarker
|
disease |
CTD_human |
Genetic and ethnic risk factors associated with drug hypersensitivity.
|
20485159 |
2010 |
|
Asthma, Aspirin-Induced
|
0.340 |
Biomarker
|
disease |
BEFREE |
Leukotriene C4 synthase has been established as a key genetic determinant of aspirin-induced asthma, but recent studies have demonstrated that several single nucleotide polymorphisms in the promoters of prostaglandin E2 receptor subtype 2, CYSLTR1 and CYSLTR2 and T-box expressed in T cells (TBX21) could increase risk for the condition.
|
16505607 |
2006 |
|
Asthma, Aspirin-Induced
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
There was no relationship between the polymorphism and the LTC4S activity in eosinophils, although LTC4S activities were significantly higher in patients with AIA than in patients with ATA.
|
12063521 |
2002 |
|
Asthma, Aspirin-Induced
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
The gene coding for LTC4 synthase exists in two common alleles, one of which appears to be associated with a severe, steroid-dependent type of aspirin-induced asthma.
|
11964666 |
2001 |
|
Asthma, Aspirin-Induced
|
0.340 |
Biomarker
|
disease |
CTD_human |
Enhanced expression of the leukotriene C(4) synthase due to overactive transcription of an allelic variant associated with aspirin-intolerant asthma.
|
10970818 |
2000 |
|
Asthma, Aspirin-Induced
|
0.340 |
Biomarker
|
disease |
CTD_human |
Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.
|
9466979 |
1998 |
|
Asthma, Aspirin-Induced
|
0.340 |
Biomarker
|
disease |
CTD_human |
Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma.
|
9393345 |
1997 |
|
Drug Allergy
|
0.300 |
Biomarker
|
group |
CTD_human |
Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant.
|
16433794 |
2006 |
|
Leukotriene C4 Synthase Deficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Peripheral Neuropathy
|
0.200 |
Biomarker
|
group |
RGD |
Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.
|
19908283 |
2010 |
|
Non-Neoplastic Peripheral Nervous System Disorder
|
0.200 |
Biomarker
|
disease |
RGD |
Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.
|
19908283 |
2010 |
|
Liver Failure, Acute
|
0.200 |
Biomarker
|
disease |
RGD |
Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model.
|
18461660 |
2008 |
|
Glomerulonephritis
|
0.200 |
Biomarker
|
disease |
RGD |
Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis.
|
7827126 |
1995 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1<i>S</i>,2<i>S</i>)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma.
|
31415176 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the -1072G/A polymorphism in the LTC4S gene with asthma in an Indian population.
|
22722751 |
2012 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that the -444A/C polymorphism in the LTC4S gene would be a risk factor for asthma in Caucasians and aspirin-tolerant populations.
|
22884858 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of expression of prostaglandin synthases 1 and 2 and leukotriene C4 synthase in aspirin-intolerant asthma: a theoretical study.
|
21331560 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The effects of the PTGDR and LTC4S polymorphisms on the enhancement of eosinophil counts were additive in the Korean children with asthma.
|
21307858 |
2011 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The over-expression of the LTC(4) synthase in a mouse asthma model also replicates the key features of AIA.
|
21429049 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of 927T > C CYSLTR1 and -444A > C LTC4S polymorphisms in children with asthma.
|
19080797 |
2009 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We genotyped 26 SNPs that had previously been interrogated for association with montelukast response in five candidate genes (ABCC1, ALOX5, CYSLTR1, LTA4H, LTC4S) in a population of 577 asthmatics who participated in a clinical trial comparing intermittent and continuous-release zileuton to placebo.
|
19214143 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the effects of LTC4S -444 A/C, ALOX5 -176/-147, and ALOX5AP -169/-146 on asthma susceptibility by means of a case-control study with 193 ethnically matched, unrelated individuals.
|
20128419 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Those specific variants include 2 variants in the 5-lipoxygenase gene (ALOX5) that are both associated with response to 5-lipoxygenase inhibition and to leukotriene receptor antagonists, variants in genes encoding the 2 established cysteinyl leukotriene receptor antagonists (CYSLTR1 and CYSLTR2) that are both associated with asthma susceptibility in at least 2 independent populations, and a leukotriene C(4) synthase promoter polymorphism (LTC4s) that has been associated with asthma affection status and asthma-exacerbated respiratory disease.
|
19665766 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As previous studies have shown that cysteinyl leukotrienes are important mediators in exercise-induced bronchoconstriction (EIB), and leukotriene receptor antagonists (LTRAs) such as montelukast have been shown to improve post-exercise bronchoconstrictor responses, we herein investigated whether clinical responsiveness to montelukast was associated with polymorphisms in the genes encoding leukotriene C4 synthase (LTC4S) and cysteinyl leukotriene receptor 1 (CysLTR1) and/or clinical parameters in Korean asthmatic children with EIB.
|
17883728 |
2007 |