LTC4S, leukotriene C4 synthase, 4056

N. diseases: 50; N. variants: 3
Disease: aspirin sensitivity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0741250
Disease: aspirin sensitivity
aspirin sensitivity 		0.020 GeneticVariation phenotype BEFREE Although the LTC4S polymorphism has previously been associated with aspirin-sensitive asthma, this is the first demonstration that the polymorphism is associated with CHES and this is independent of aspirin sensitivity. 17063752 2007
CUI: C0741250
Disease: aspirin sensitivity
aspirin sensitivity 		0.020 GeneticVariation phenotype BEFREE We sought to screen the LTC(4) synthase gene for polymorphisms and to determine whether there is an association between these polymorphisms and asthma severity or aspirin sensitivity in a large, well-phenotyped population and to determine whether this polymorphism is functionally relevant. 15131571 2004