|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the present study, patient tumor tissues, ex-vivo cultures of patient-derived xenografts (PDX), PDAC stellate and tumor cells were used to investigate whether hypoxia (1% O<sub>2</sub>) within the tumor microenvironment influences stromal lumican expression and secretion.
|
30283082 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Both decorin and lumican are putative tumor suppressors with additional functions in angiogenesis, fibrosis, inflammation and autophagy.
|
30711828 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tissue expression of lumican, a class II SLRP, was associated with clinical outcome and appears tumour specific.
|
30629950 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The LUM Imaging System allows rapid identification of residual tumor in the lumpectomy cavity of breast cancer patients and may reduce rates of positive margins.
|
29948401 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lumican and versican expression were both observed in neoplastic cells and in the tumor stroma of colon adenomas and carcinomas.
|
28481899 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Altogether, the results obtained present lumican as a strong endogenous inhibitor of tumor growth, while identifying for the first time this proteoglycan as a major driver of tumor matrix coherent assembly.
|
28794454 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, lumican expression was not associated with tumor grade, stage, and vascular/pleural invasion.
|
25961303 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Lumican was present in the stroma surrounding PDAC cells in roughly one-half of primary tumors and the direct xenografts.
|
25336691 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Validation of the results was performed by paired and unpaired t test in primary GCTB and corresponding metastases, which proved that the differential expression of LUM and DCN is tumor specific rather than location specific.
|
25304290 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Lumican was shown to impede tumour cell migration and invasion by directly interacting with the α2β1 integrin.
|
23438179 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previous works from our group showed that lumican inhibited melanoma cell migration and tumor growth in vitro and in vivo.
|
24098450 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Lumican, a tumor suppressor that inhibits EMT, was found to be transcriptionally repressed by HMGA2 and was frequently lost in human high-grade serous papillary carcinoma.
|
21224353 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In ADC, the expression level of lumican in cancer cells correlated with pleural invasion and larger tumor size, but that of lumican in stromal tissues did not correlate with clinicopathological factors.
|
19020750 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lumican expression in pancreatic cancer cells did not correlate with clinicopathological factors, whereas lumican expression in stromal tissues correlated with the female gender, advanced stage, retroperitoneal and duodenal invasion and residual tumor (p=0.030, 0.038, 0.049, 0.049 and 0.048, respectively).
|
17671699 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results indicate that the higher expression level of cytoplasmic lumican in carcinoid tumors than in NECs may play a role in the slow growth of these tumors.
|
15753980 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, normal salivary glands express lumican, which appears to be related to stromal maintenance, and pleomorphic adenomas express lumican mRNA and protein, which may play important roles in the formation of 'mesenchyme'-like areas in this type of tumour.
|
15258999 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
After subcutaneous injections of transfected B16F1 cells in syngenic mice, lumican expression significantly decreased subcutaneous tumor formation in vivo, with a concomitant decrease of cyclin D1 expression.
|
15149859 |
2004 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The tumour lumican had non- or poorly sulphated polylactosamine side-chains rather than highly sulphated keratan sulphate chains.
|
11857496 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Higher lumican expression was associated with higher tumor grade, lower estrogen receptor levels in the tumor, and younger age of the patients (P < 0.05).
|
9537227 |
1998 |