LUM, lumican, 4060

N. diseases: 123; N. variants: 6
Disease: Severe myopia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE LUM c.507 polymorphism may be a risk factor for the pathogenesis of high myopia in the Southern Chinese population. 29062769 2017
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE Chinese lumican rs3759223 C allele carriers may be at reduced risk of high myopia. 24516061 2014
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE Lack of association between LUM rs3759223 polymorphism and high myopia. 24927138 2014
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE This meta-analysis aims to comprehensively evaluate the relationship between two common LUM polymorphisms (rs3759223 and rs3759222) and the risk of high myopia. 24956166 2014
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE The current study did not support an association between the promoter SNPs of the LUM gene with high myopia in the Korean population. 23145541 2013
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE Association of Lumican gene polymorphism with high myopia: a meta-analysis. 24061151 2013
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 Biomarker disease BEFREE Our results confirm that the PAX6, Lumican, and MYOC genes were not associated with high myopia in the Han Chinese in Northeastern China. 22809227 2012
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE PURPOSE.To investigate the relationship between high myopia and single nucleotide polymorphisms (SNPs) in six proteoglycan genes: aggrecan (ACAN), fibromodulin (FMOD), decorin (DCN), lumican (LUM), keratocan (KERA), and epiphycan (EPYC). 21743019 2011
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE These observations suggest that the four polymorphisms of the LUM promoter contribute to the pathogenesis of high myopia. 20010793 2010
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE Single-nucleotide polymorphisms (SNPs) in the LUM gene were determined in an investigation of whether LUM gene polymorphisms correlate with high myopia. 19643966 2010
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE The lumican gene SNP rs3759223:T-->C demonstrated a significant association with high myopia (P = 2.83 x 10(-4)). 19616852 2009
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE Analysis of 85 English and 40 Finnish subjects with high myopia (refractive error of -6 diopters [D] or greater) resulted in 23 sequence variations in four SLRP genes, LUM, FMOD, PRELP, and OPTC. 17117407 2007
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE Our results indicate that an SNP (rs3759223), which is located in the promoter region of the lumican gene, may be worth further investigation to determine its association with development of high myopia. 16902402 2006
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.100 GeneticVariation disease BEFREE Lumican maps within the chromosome 12q21-q23 autosomal dominant high grade myopia-3 (MYP3) interval, and fibromodulin maps to chromosome 1q32. 15592176 2004