SH2D1A, SH2 domain containing 1A, 4068

N. diseases: 160; N. variants: 8
Disease: Graves Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.030 GeneticVariation disease BEFREE The C1858T polymorphism of the PTNP22 gene reduces the expression of its encoded LYP, which increases the risk of GD and HT. 28133421 2017
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.030 GeneticVariation disease BEFREE Recently, a gain of function variant C1858T of the lymphoid-specific protein tyrosine phosphatase non-receptor (LYP, PTPN22) gene has been reported to be associated with several autoimmune disorders including Graves' disease, type 1 diabetes, rheumatoid arthritis and vitiligo. 16893384 2006
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.030 GeneticVariation disease BEFREE The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease. 15531553 2004