|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Background:</b> Inactivation of microRNA-100 (miR-100) is involved in hepatocellular carcinoma (HCC) and miR-100 behaves as a tumor suppressor.
|
31293973 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Abundant hsa-circ-0072309 induced the inhibitions of cell proliferation, migration and invasion, as well as the PI3K/AKT and the mTOR cascades but enhancement of apoptosis. circRNA stimulated the down-regulation of miR-100, which was low-expressed in tumour tissue and whose overproduction abolished the impacts of circRNA on these elements mentioned above.
|
31456425 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interfering miR-100 expression of TAMs in mouse breast cancer model could inhibit TAMs pro-tumor function and reduce tumor metastasis, which suggests that miR-100 could serve as a potential therapy target to remodel tumor microenvironment in breast cancer.
|
30563983 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MiR-100 actively participates to the regulation of mTOR expression in lung carcinoids and represents a novel candidate prognostic biomarker for this tumor type; moreover, inhibition of its expression is associated to increased responsiveness to mTOR inhibitors and might represent a novel strategy to sensitize lung carcinoids to these target agents.
|
29938004 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, low miR-100 expression was observed to be associated with lymph node metastasis, tumor diameter and tumor stage.
|
29422961 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MIR100HG, miR-100 and miR-125b overexpression was also observed in cetuximab-resistant colorectal cancer and head and neck squamous cell cancer cell lines and in tumors from colorectal cancer patients that progressed on cetuximab. miR-100 and miR-125b coordinately repressed five Wnt/β-catenin negative regulators, resulting in increased Wnt signaling, and Wnt inhibition in cetuximab-resistant cells restored cetuximab responsiveness.
|
29035371 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Among them is miR-100 which can exert both tumor suppressor and oncogenic functions in various cancer types.
|
29096749 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Literature search was conducted in databases such as PubMed, Embase, and Web of Science, using the following words "(microRNA-100 OR miR-100 OR mir100) AND (tumor OR neoplasm OR cancer OR carcinoma OR malignancy)."
|
28176958 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results of the current study suggest that tumor oncogene miR‑100‑5p could be used as a diagnostic biomarker for RCC.
|
28765937 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our results demonstrate that miR-100 is a tumor suppressor microRNA and indicate its potential application for the treatment of osteosarcoma in future.
|
26306402 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Vemurafenib treatment increased the CCL2 levels in plasma, whereas the long-term clinical response was associated with low CCL2 levels.Increased CCL2 production was associated with miRNA deregulation in the resistant cells. miR-34a, miR-100 and miR-125b showed high expression in both resistant cells and in tumor biopsies that were obtained from treated patients, and they were involved in the control of cell proliferation and apoptosis.
|
26684239 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
miR-100 suppresses the proliferation and tumor growth of esophageal squamous cancer cells via targeting CXCR7.
|
27035873 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MicroRNA-100 functions as a tumor suppressor by inhibiting Lgr5 expression in colon cancer cells.
|
25483280 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our in vivo assays indicated that the development of gastric cancer was inhibited by the miR-100 antagonism via initiating apoptosis of tumor.
|
25703026 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The key role played by miR-100 in breast cancer free-survival is confirmed by the analysis of a cohort of patients' tumors, which shows that low expression of miR-100 is a negative prognostic factor and is associated with gene signatures of high grade undifferentiated tumors.
|
25537513 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of miR-100 suppressed tumor growth in vivo and inhibited gastric cancer invasion and metastasis in vitro and in vivo.
|
26404754 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A low miR-100 expression level was correlated with tumor stage (P = 0.023), tumor grade (P = 0.031), and regional lymph node involvement (P = 0.16).
|
26662386 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Similarly, miR-100 has been reported as a tumor suppressor by controlling cell migration and invasion, as it can target mTOR genes.
|
25109390 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overexpressing miR-100 led to significant inhibition on tumor formation in vivo.
|
25344675 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, we consider that miR-100 acts as a tumor suppressor for osteosarcoma.
|
24317814 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In summary, the present studies highlight miR-100 as a tumor suppressor in chondrosarcoma contributing to anti-chemoresistance.
|
24568519 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data indicate that the miR-100 plays a tumor suppressor role by regulating colorectal cancer cell growth and invasion phenotype, and could serve as a potential maker for colorectal cancer therapy.
|
24626817 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Also, low miR-100 expression was observed to be significantly correlated with larger tumor size (P=0.023), higher incidence of lymph node metastasis (P=0.009), and advanced TNM stage (P=0.016).
|
25216869 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, miR-100 may act as a tumor suppressor in bladder cancer, and reintroduction of this mature miRNA into tumor tissue may prove to be a therapeutic strategy by reducing the expression of target genes.
|
23270926 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This suggests that miR-100 may be a context-dependent miRNA, acting as oncogene or tumor suppressor miRNA.
|
23778488 |
2013 |