|
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although microRNA-29b (miRNA-29b) and microRNA-122 (miRNA-122) have great potential in treating liver fibrosis via regulating profibrotic genes in hepatic stellate cells (HSCs), it is still a challenge to achieve a HSC-targeted and meanwhile noninvasively trackable delivery of miRNAs in vivo.
|
30886803 |
2019 |
|
Fibrosis, Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, FoxO1 increased miR-122 and pri-miR-122 (primary miR-122) levels in HSCs in vivo, and reduced leptin-induced HSC activation and liver fibrosis in ob/ob mouse (leptin deficient) model.
|
29248466 |
2018 |
|
Fibrosis, Liver
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study provides partial evidence that STF-083010 alleviated CCl<sub>4</sub>-induced liver injury and thus protected against liver fibrosis associated with hepatic miR-122.
|
30538632 |
2018 |
|
Fibrosis, Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6.
|
28864835 |
2017 |
|
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further experiments indicated that miR-122 inhibited leptin-induced liver fibrosis in leptin-deficient mouse model.
|
29054053 |
2017 |
|
Fibrosis, Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A lower serum miR-122 level is a useful predictor of advanced liver fibrosis in HBV-infected patients.
|
28475652 |
2017 |
|
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma miR-122 and miR-21 had strong correlation with degree fibrosis in HCV genotype-4 patients; consequently they can be considered as potential biomarker for early detection of hepatic fibrosis.
|
28642869 |
2017 |
|
Fibrosis, Liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results demonstrate that miR-122 modification improves the therapeutic efficacy of AMSCs through exosome-mediated miR-122 communication; thus, miR-122 modification is a new potential strategy for treatment of liver fibrosis.
|
28544786 |
2017 |
|
Fibrosis, Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of miR-122 in advanced fibrosis and its correlation with fibrosis stage and LS values seem to be characteristic of hepatic fibrosis of various etiologies.
|
26167081 |
2015 |
|
Fibrosis, Liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that miR-21 expression correlated with viral load, fibrosis and serum liver transaminase levels. miR-122 expression inversely correlated with fibrosis, liver transaminase levels and patient age. miR-21 was induced ∼twofold, and miR-122 was downregulated on infection of cultured cells with the HCV J6/JFH infectious clone, thus establishing a link to HCV.
|
20625373 |
2010 |