MIR122, microRNA 122, 406906

N. diseases: 250; N. variants: 3
Disease: Dilated cardiomyopathy secondary to metabolic disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0264802
Disease: Dilated cardiomyopathy secondary to metabolic disorder
Dilated cardiomyopathy secondary to metabolic disorder 		0.010 Biomarker disease BEFREE Mechanistically, miR-122 directly bound and suppressed mitochondrial protein ADP-ribosylation factor-like 2 (Arl-2) <i>in vitro</i> and <i>in vivo</i> Knockdown of <i>Arl-2</i> abolished the mitochondrial benefits of miR-122 sponge in exosome-treated mouse primary cardiomyocytes.In conclusions, our present study firstly showed that liver-secreted exosomal miR-122 played a critical role in the development of metabolic cardiomyopathy, and miR-122/mitochondrial Arl-2 signaling affected cardiac energy homeostasis. 31434696 2019