Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of note, the expression profile of APOBEC2 in the Huh7 and HepG2 liver cancer cell lines opposed that of miR‑122; this miR is the most abundant miRNA in the liver and has been associated with hepatocarcinogenesis.
|
31485598 |
2019 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
The miRNA nanotherapeutics, activatable by stepwise stimulation of acidity and reduction mimicking tumor microenvironment, efficiently improve liver-specific miR-122 expression, increasing the possibility of translational application of miR-122 therapy against liver cancer.
|
31317136 |
2019 |
Malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer.
|
29904144 |
2018 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
miRNA122a regulation of gene therapy vectors targeting hepatocellular cancer stem cells.
|
29805757 |
2018 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer.
|
28735896 |
2017 |
Malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of microRNA-122 and microRNA-22 in HBV-related liver cancer and the correlation with clinical features.
|
28272709 |
2017 |
Malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The anti-cancer effects of cisplatin on hepatic cancer are associated with modulation of miRNA-21 and miRNA-122 expression.
|
27874954 |
2016 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicate that serum miR-122 and miR-222 are elevated in Egyptian patients with chronic HCV, and these miRNAs have a strong potential to serve as novel biomarkers for liver injury but not specifically for liver cancer.
|
26812693 |
2016 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis.
|
26987776 |
2016 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that enhanced glycolysis is associated with CD133 (+) stem-like characteristics and that metabolic reprogramming through miR-122 or PDK4 may represent a novel therapeutic approach for the treatment of hepatocellular cancer.
|
26506419 |
2015 |
Malignant neoplasm of liver
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis results showed that miR-let-7c Del, miR-34b/c C, and miR-122 Del variants may be associated with increased liver cancer risk.
|
25078599 |
2014 |
Malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2.
|
24038073 |
2014 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
The elevation in miR-122 was correlated with liver damage in CHB patients and with the pathogenesis of liver cancer in HCC patients.
|
25299106 |
2014 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data strongly suggest that miR-122 is a tumor suppressor that targets AKT3 to regulate tumorigenesis in HCCs and a potential therapeutic candidate for liver cancer.
|
24244539 |
2013 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers.
|
24386085 |
2013 |
Malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RNA was extracted from 195 sera of HCC patients and 54 patients with liver cirrhosis, obtained at the time of study enrolment. miR-1 and miR-122 levels were correlated with overall survival (OS), Cancer of the Liver Italian Program (CLIP) score, Barcelona Clinic Liver Cancer stage, clinical chemistry parameters and tumor specific treatment.
|
23810247 |
2013 |
Malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression profiling using clone count analysis was used to identify miRNAs that are expressed aberrantly in liver cancer including miR-122, miR-21, and miR-34a.
|
21283620 |
2011 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, miR-122 regulates mitochondrial metabolism and its loss may be detrimental to sustaining critical liver function and contribute to morbidity and mortality of liver cancer patients.
|
20739924 |
2010 |
Malignant neoplasm of liver
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties.
|
19617899 |
2009 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these results suggest that the loss of multifunctional miR-122 contributes to the malignant phenotype of HCC cells, and miR-122 mimetic alone or in combination with anticancer drugs can be a promising therapeutic regimen against liver cancer.
|
19726678 |
2009 |
Malignant neoplasm of liver
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the downregulation of miR-122 is associated with hepatocarcinogenesis and could be a potential biomarker for liver cancers.
|
16924677 |
2006 |