Association of miRNA polymorphisms with prognosis outcomes was examined by the Kaplan-Meier method, log-rank test, and Cox proportional hazards models. miR-122rs17669 was significantly associated with recurrence risk of ischemic stroke under the recessive model.
However, the three other miRNA (miR-143 rs4705342, miR-122rs17669, and miR-124 r531564) were not associated with IS risk under allele or genotype, nor in different inheritance models.
Two miRNAs (miR-145 and miR-122) may represent potential biomarkers in ischemic stroke by being involved in the process of postischemic neuronal damage and thrombosis, respectively.