MIR127, microRNA 127, 406914

N. diseases: 105; N. variants: 0
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.370 AlteredExpression disease BEFREE miR-127 is downregulated in breast cancer, where it has been shown to suppress the proliferation, migration and invasion of breast cancer cells. 31694904 2020
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.370 AlteredExpression disease BEFREE The RQ of plasma miR-127-3p in BC patients was significantly higher than that in benign breast tumor patients and healthy individuals (both P< 0.001), and there was no significant difference between benign breast tumor patients and healthy individuals (P> 0.05). 27983524 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.370 PosttranslationalModification disease BEFREE Additionally, we also found a strong association between hypermethylation of MIR-127 and MIR-125b-1 and BC progression, particularly metastasis. 27998789 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.370 Biomarker disease BEFREE Therefore, miR-127 may be a potential biomarker for predicting the survival of BC patients and might be a molecular target for treatment of human BCs. 25477702 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.370 AlteredExpression disease BEFREE Moreover, overexpression of miR-127 reduced the in vitro migration and proliferation ability of breast cancer cell MDA-MB-231. 24155205 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.370 AlteredExpression disease BEFREE Over-expression of miR-127 or depletion of BCL6 inhibits breast cancer cell proliferation. 24282530 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.370 Biomarker disease BEFREE Circulating miR-127-3p, miR-376a and miR-652, selected as candidates from a miRNA array-based screening, were found to be associated with breast cancer for the first time (n = 417). 24194846 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.370 Biomarker disease CTD_human Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. 20099276 2010