MIR130B, microRNA 130b, 406920

N. diseases: 115; N. variants: 1
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 GeneticVariation disease BEFREE Genetic associations between the miRNA polymorphisms miR-130b (rs373001), miR-200b (rs7549819), and miR-495 (rs2281611) and colorectal cancer susceptibility. 31117970 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 AlteredExpression disease BEFREE Further, treatment of CRC cells with TGF-β1 caused a significant decrease in the expression of miR-130b and an increased CRC cell migration. 26873488 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 AlteredExpression disease BEFREE In the overexpression miR-130b CRC cells and the CRC specimens, we observed a decreased level of integrin β1 protein, which is considered as a key molecule involved in cell motility. 24498407 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 Biomarker disease BEFREE Since higher levels of miR-130b are found in advanced tumor stages (III-IV), we propose a novel role of the miR-130b-PPARγ axis in fostering the progression toward more invasive CRCs. 24027433 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.340 Biomarker disease CTD_human Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors. 22510560 2012