MIR140, microRNA 140, 406932

N. diseases: 144; N. variants: 2
Disease: Cleft palate, isolated ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1837218
Disease: Cleft palate, isolated
Cleft palate, isolated 		0.040 Biomarker disease BEFREE The role of miR-140, which had the strongest association with CP, was investigated in both human and mouse palate cells. 31589286 2019
CUI: C1837218
Disease: Cleft palate, isolated
Cleft palate, isolated 		0.040 GeneticVariation disease BEFREE PCR-sequencing of the entire coding regions and the 3' untranslated region (UTR) of the platelet-derived growth factor receptor alpha (PDGFRa) and the microRNA (miR), miR-140 identified seven novel single base-pair substitutions in the PDGFRa in 9/102 patients with CP (8.8%), compared with 5/500 ethnic-matched unaffected controls (1%) (the two-tailed P-value<0.0001). 22473090 2012
CUI: C1837218
Disease: Cleft palate, isolated
Cleft palate, isolated 		0.040 GeneticVariation disease BEFREE Therefore, we sought to investigate whether the A allele of rs7205289 and maternal smoke exposure during the first trimester might contribute to cleft palate risk by regulating microRNA-140. 22012839 2011
CUI: C1837218
Disease: Cleft palate, isolated
Cleft palate, isolated 		0.040 GeneticVariation disease BEFREE Single nucleotide polymorphism associated with nonsyndromic cleft palate influences the processing of miR-140. 20358594 2010