|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results revealed that the expression of miR‑145 was significantly (P<0.05) downregulated in colon adenocarcinoma cells and the ectopic expression of miR‑145 in colon cancer inhibited proliferation by promoting the apoptosis of SW480 primary colon adenocarcinoma cells.
|
30272312 |
2018 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have observed that modulated expression of CCAT2 regulates the expression of miR-145 in colon cancer HCT-116 and HT-29 cells.
|
28964256 |
2017 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we study a PLGA/PEI (poly (d, l-lactide-co-glycolide)/polyethylenimine)-mediated miRNA vector delivery system; the validation of the method was carried out using a colon cancer xenograft model with miR-145 vector encoding for the expression of miR-145 (pDNA).
|
27482839 |
2016 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of lincRNA-ROR restored the expression of miR-145, and had a significant influence on colon cancer cell proliferation, migration and invasion.
|
27071407 |
2016 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1.
|
27626692 |
2016 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
miR-145 is important in inhibiting colon cancer cell proliferation and migration.
|
26973415 |
2016 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
miR-143 and miR-145 are downregulated in colon cancer.
|
26824186 |
2016 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Primary transcripts and mature miR-143 and miR-145 were quantified by real-time PCR, putative targets were measured by Western blotting, and DNA methylation was assessed by sequencing bisulfite-treated DNA in proximal and distal normal colonic mucosa as well as colon cancers.
|
25477374 |
2015 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these data suggested that miR-145 plays a pivotal role in colon cancer through inhibiting cell proliferation migration and invasion, and miR-145 may serve as a tumor suppressor by targeting paxillin gene.
|
25973017 |
2015 |
|
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Most notable associations were for hsa-miR-145-3p [hazard ratio (HR) 2.94, 95% confidence interval (CI) 1.54, 5.61], and hsa-miR-9-3p (HR 10.28, 95% CI 1.31, 80.84) with colon cancer and hsa-miR-335-5p (HR 0.17, 95% CI 0.05, 0.54) for rectal cancer. hsa-miR-374a-5p, hsa-miR-570-3p and hsa-miR-18a-5p significantly reduced the hazard of dying for all cases, regardless of tumor site.
|
25484364 |
2015 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to examine the expression pattern of the miR-17-92 cluster (miR-17, miR-18, miR-19, miR-20 and miR-92) as well as miR-21, miR-31, miR-135b, and miR-145 in early clinically diagnosed colon cancer.
|
26465597 |
2015 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our current observations suggest that miR-21, miR-145, and their networks play critical roles in regulating CSCs growth and/or differentiation in the colon cancer and progression of chemo-resistance.
|
25928322 |
2015 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrated that miR-145 and miR-1 play a negative regulatory role in the proliferation of colon cancer by targeting NAIP; thus, miR-145 and miR-1 may prove to be novel therapeutic targets in the treatment of colon cancer.
|
26459459 |
2015 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
microRNA‑145 (miR‑145) has been reported to be frequently downregulated in various types of cancer, including renal, prostate, bladder, lung and colon cancer, as well as B‑cell malignancies.
|
24737449 |
2014 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Restoring miR-143 and miR-145 in colon cancer cells decreases proliferation, migration and chemoresistance.
|
23128394 |
2013 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
miR-143 and miR-145 are believed to function as colon cancer tumor suppressors, as they inhibit colon cancer cell growth and are downregulated in sporadic colonic tumors.
|
21557394 |
2012 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using SILAC, we identified over 2000 proteins after reintroduction of miR-143 and miR-145, in the colon cancer cell line SW480, individually, and then, in concert.
|
22897626 |
2012 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Down-regulated expression of miR-145 has been reported in colon cancer tissues and cell lines.
|
22766504 |
2012 |
|
Malignant tumor of colon
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the miR-145 level is inversely correlated with the amount of p70S6K1 protein in colon cancer tissues.
|
21917858 |
2012 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that miR-145 functions as a tumor suppressor by down-regulating oncogenic FLI1 in colon cancer.
|
20737575 |
2011 |
|
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rodent and human sporadic and ulcerative colitis (UC)-associated colon cancers were examined for miR-143 and miR-145.
|
21653642 |
2011 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the role of miR-145 in colon cancer, we have employed a microarray based approach to identify miR-145 targets.
|
20098684 |
2010 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increasing evidence indicates that miR-145 is a tumor suppressor capable of inhibiting breast and colon cancer cell growth both in vitro and in vivo.
|
21092188 |
2010 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
The transfection of human gastric MKN-1 cells with miR-145 resulted in a greater growth inhibitory effect than that with miR-143, results which were contrary to those in colon cancers.
|
19439999 |
2009 |
|
Malignant tumor of colon
|
0.100 |
Biomarker
|
disease |
BEFREE |
An IGF-IR resistant to miR145 (again by elimination of its 3' UTR) is not down-regulated by miR145 but fails to rescue colon cancer cells from growth inhibition.
|
19391107 |
2009 |