Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Subgroup analysis based on tumor type showed that the downregulation of miR-145 was associated with unfavorable OS in colorectal cancer (HR = 2.17; 95% CI, 1.52-3.08; <i>P</i> < 0.001), ovarian cancer (HR = 2.15; 95% CI, 1.29-3.59; <i>P</i> = 0.003), gastric cancer (HR = 1.78; 95% CI, 1.35-2.36; <i>P</i> < 0.001), glioma (HR = 1.65; 95% CI, 1.30-2.10; <i>P</i> < 0.001), and osteosarcoma (HR = 2.28; 95% CI, 1.50-3.47; <i>P</i> < 0.001).
|
30602498 |
2019 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we demonstrated that miR-145-3p has inhibited the malignant behavior of osteosarcoma by down-regulating HDAC4 expression.
|
29893594 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this work, the main goal was centered on the development and full characterization of an efficient micellar nanosystem, based on the chemical conjugation between the amphiphilic copolymer Pluronic® L64 and the cationic polymer polyethyleneimine (PEI), to deliver the therapeutic miRNA-145 into OS cells leading to inhibition of cell proliferation and migration, and ultimately inducing cell death, crafting a novel anticancer therapeutic approach to OS.
|
30010029 |
2018 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, miR-145 was downregulated in OS tissues and cell lines and it was shown that miR-145 expression was closely correlated with advanced tumor progression in patients of OS.
|
28186090 |
2017 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Human osteosarcoma cell line OS-732 was used for high and low expressions of microRNA-145.
|
25926306 |
2016 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that miR-145 acts as a tumor suppressor by directly reducing expression of FLI-1, and that the miR-145/FLI-1 pathway is important for tumor progression in OS.
|
27304058 |
2016 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, the expression of miR-145 was mediated by a constructed lentivirus vector to inoculate nude mice to observe the inhibiting effect of miR-145 in OS in vivo.
|
28051259 |
2016 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified MMP16 as a target gene of miR-145 and ruled out ADAM17 and metadherin as targets in OS using a dual luciferase reporter system.
|
26605780 |
2015 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To the best of our knowledge, the present study demonstrates for the first time that, as a tumor suppressor, miRNA‑145 inhibits OS cell proliferation and invasion, at least in part by directly targeting ROCK1.
|
24789502 |
2014 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these data indicate that miR-145 may act as a tumor suppressor and contributes to the progression of OS through targeting ROCK1.
|
24801908 |
2014 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma.
|
23430952 |
2013 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, it can be concluded that miR-145 can inhibit invasion and metastasis of osteosarcoma cells.
|
22472569 |
2012 |