|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report increased SERPINB2 expression in the skin of psoriasis patients, which was in a positive relationship with psoriasis severity and in a negative relationship with miR-146a/b in psoriatic lesions.
|
31630447 |
2020 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of rs2910164 polymorphism in MiR-146a gene with psoriasis susceptibility: A meta-analysis.
|
30732186 |
2019 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2.
|
29279330 |
2018 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether the miR-146a rs2910164 contributes towards psoriasis and PsA development in South African Indian and Caucasian patients.
|
29587639 |
2018 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The severity of psoriasis-like skin inflammation was evaluated at morphologic, histologic, and molecular levels. miR-146a was ectopically overexpressed and inhibited in keratinocytes treated with IL-17.
|
27568078 |
2017 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In silico analysis of genome-wide data from >4,000 psoriasis cases and >8,000 controls confirmed a moderate association between psoriasis and genetic variants in the miR-146a encoding gene.
|
28595995 |
2017 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We suggest that both miR-146a and miR-99a may serve as potential biomarkers for disease activity and clinical efficacy in psoriasis patients treated with ZG.
|
27562321 |
2016 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is found that genetic polymorphisms related to some of specific miRNAs, miR-146a for example, are associated with psoriasis susceptibility.
|
26559308 |
2015 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, combination of serum levels of miR-146a-5p and -203a-3p was more reliable to distinguish psoriasis patients and normal subjects, than each miRNA alone.
|
25917002 |
2015 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that the rs2910164G allele in miR-146a weakens its suppression on the proliferation of keratinocytes probably through the decreased inhibition of the target gene, EGFR, which may account for the increased risk of psoriasis in this study population.
|
25209759 |
2014 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By inhibiting target gene expression, microRNAs (miRNAs) play major roles in various physiological and pathological processes. miR-146a, a miRNA induced upon lipopolysaccharide (LPS) stimulation and virus infection, is also highly expressed in patients with immune disorders such as rheumatoid arthritis, Sjögren's syndrome, and psoriasis.
|
23645835 |
2013 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inability of miR-146a inhibiting target gene IRAK1 may contribute to the persistent inflammation in lesions of psoriasis.
|
23018031 |
2012 |