MIR146A, microRNA 146a, 406938

N. diseases: 505; N. variants: 3
Disease: Thrombocytosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis 		0.030 Biomarker disease BEFREE Recent evidence suggests that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. 22571696 2012
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis 		0.030 Biomarker disease BEFREE Other mouse modeling data suggest that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. 20733155 2010
CUI: C0836924
Disease: Thrombocytosis
Thrombocytosis 		0.030 AlteredExpression disease BEFREE Knockdown of miR-145 and miR-146a together or enforced expression of TRAF6 in mouse HSPCs resulted in thrombocytosis, mild neutropenia and megakaryocytic dysplasia. 19898489 2010