|
Noise-induced hearing loss
|
0.300 |
Biomarker
|
disease |
CTD_human |
The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma.
|
23472202 |
2013 |
|
Myocardial Reperfusion Injury
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Modulation of microRNA 20b with resveratrol and longevinex is linked with their potent anti-angiogenic action in the ischaemic myocardium and synergestic effects of resveratrol and γ-tocotrienol.
|
22050707 |
2012 |
|
Hepatoma, Morris
|
0.300 |
Biomarker
|
disease |
CTD_human |
Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages.
|
21035526 |
2011 |
|
Hepatoma, Novikoff
|
0.300 |
Biomarker
|
disease |
CTD_human |
Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages.
|
21035526 |
2011 |
|
Liver Neoplasms, Experimental
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages.
|
21035526 |
2011 |
|
Experimental Hepatoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages.
|
21035526 |
2011 |
|
Cocaine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction.
|
20643829 |
2010 |
|
Cocaine-Related Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction.
|
20643829 |
2010 |
|
Cocaine Dependence
|
0.300 |
Biomarker
|
disease |
CTD_human |
Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction.
|
20643829 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, xenograft tumors induced by A549/DDP cells exerted cisplatin resistance, and miR-186-5p overexpression could inhibit tumor growth under DDP treatment.
|
31686523 |
2020 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of the present study was to determine the expression characteristics, biological function and molecular mechanisms of miR‑186‑5p, which is associated with cancer development and progression, in osteoblastic differentiation and cell viability.
|
31702033 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previous studies have revealed that miR-186 is involved in the pathogenesis of many malignancies.
|
31140612 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, this evidence highlights the potential value of miR-186 in the diagnosis, prognosis and treatment of human cancer.
|
31525641 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MicroRNAs (miRs), a class of small non-coding RNAs, have been demonstrated to be involved in the development and progression of human malignancies, including cutaneous squamous cell carcinoma (CSCC). miR-186 serves a suppressive role in certain common types of human cancer; however, its exact function in CSCC has not been reported previously.
|
30867688 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Downregulation of miR-186 was associated with tumor metastasis and a poor overall survival in patients with BC.
|
30552711 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Loss-of-function experiments showed that reduction of miR-186 dramatically enhanced tumor cell proliferation and metastasis.
|
31140612 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Besides, compared with the miR-NC group, the microRNA-186-5p mimics group had a significant decrease in proliferation and metastasis ability of ECa cells.
|
31802902 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
MORC2 promotes cell growth and metastasis in human cholangiocarcinoma and is negatively regulated by miR-186-5p.
|
31180332 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Further assays demonstrated that miR-186-5p overexpression had inhibitory effects on in-vitro cell proliferation, cell cycle, and in-vivo tumor growth. miR-186-5p overexpression also inhibited the epithelial-tomesenchymal transition (EMT), migration and invasion of OS cells.
|
30897321 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings suggest that miR-186 functions as a tumor suppressor by targeting Twist1 in BC. miR-186 may serve as a novel biomarker in BC diagnosis or a new therapeutic target in BC treatment.
|
30552711 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Restoration of miR-186 levels in neuroblastoma through NK cell-derived exosomes or by nanoparticle delivery reduces tumor burden, promotes survival, and restores the cell-killing abilities of NK cells, demonstrating the therapeutic potential of tumor-suppressive miRNAs in neuroblastoma.<i>See related article by Neviani and colleagues; Cancer Res 79(6):1151-64</i>.
|
30936073 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the present study, the expression of miR-186 was significantly increased in CSCC tissues compared with adjacent non-tumour tissues.
|
30867688 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Altogether, these data support the investigation of a miR-186-containing nanoparticle formulation to prevent tumor growth and TGFβ1-dependent immune escape in high-risk neuroblastoma patients as well as the inclusion of <i>ex vivo</i>-derived NK exosomes as a potential therapeutic option alongside NK cell-based immunotherapy.<b>Significance:</b> These findings highlight the therapeutic potential of NK cell-derived exosomes containing the tumor suppressor miR-186 that inhibits growth, spreading, and TGFβ-dependent immune escape mechanisms in neuroblastoma.
|
30541743 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, our data revealed that HIF-1α was a downstream target of miR-186-5p and that NEAT1 could exert its tumor oncogenic roles on OS cells via the miR-186-5p/HIF-1α axis.
|
30485482 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In a word, our study found that miR-186-5p could inhibit tumor proliferation by targeting Eg5 in neuroblastoma.
|
31105832 |
2019 |