MIR19A, microRNA 19a, 406979

N. diseases: 151; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 Biomarker disease BEFREE Profilin 1, negatively regulated by microRNA-19a-3p, serves as a tumor suppressor in human hepatocellular carcinoma. 30638858 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 Biomarker disease BEFREE Hsa-mir-19a was identified as showed different effects in the three HCC differential regulation networks, and showed vital regulatory role in HBV-related HCC. 31729887 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 Biomarker disease BEFREE Therefore, miR‑19a may have potential as a novel molecular marker for HCC and Pter may be a promising clinical target with the potential to be developed as a HCC therapy. 29393488 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 AlteredExpression disease BEFREE In conclusion, ectopic expression of miR-19a-3p contributes to HCC metastasis and chemoresistance by modulating PTEN expression and the PTEN-dependent pathways. 30021351 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 AlteredExpression disease BEFREE The expression of miR-18a and miR-19a (belonging to miR-17 cluster) increased in HCC cells by CXCL8 simulation and led to the enhancement of HCC cell proliferation and metastasis. 28559990 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 AlteredExpression disease BEFREE Our data show that miR-19a and miR-96, whose expression is regulated by ANT2 suppression, were markedly upregulated in HCC cell lines and clinical samples. 27012708 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 AlteredExpression disease BEFREE MiR-19a showed an up-regulation in HBV-positive HCC patients compared to healthy controls and HBV-negative HCC patients, while miR-122 and miR-223 showed a down-regulation compared to healthy controls, and miR-122 in HBV-positive HCC patients was also down-regulated when compared to HBV-negative HCC patients. 27150195 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.080 Biomarker disease BEFREE Among them, hsa-miR-19a, hsa-miR-19b1 and the corresponding precursors were down-regulated by panobinostat in TP53(-/-) Hep3B and TP53(+/+) HepG2 cell lines; hsa-miR30a-5p mature form only was suppressed in both HCC cell lines, as confirmed by further RT-qPCR analysis. 24375802 2015