|
Mammary Neoplasms
|
0.380 |
AlteredExpression
|
group |
BEFREE |
Analysis of breast tumor gene expression datasets revealed an inverse association between miR-200c and PDE7B expression.
|
30209363 |
2019 |
|
Mammary Neoplasms
|
0.380 |
Biomarker
|
group |
BEFREE |
Finally, quantification of miR-200c in breast cancer stem cells (BCSCs) and in stem cells isolated from breast tumors was performed.
|
31246422 |
2019 |
|
Mammary Neoplasms
|
0.380 |
Biomarker
|
group |
BEFREE |
<i>Conclusions</i>: Our results indicated that miR-200c/141 played biphasic roles in breast tumor progression via affecting the BCSC heterogeneity, suggesting targeting BCSC heterogeneity to simultaneously restrict breast cancer initiation and metastasis could be a promising therapeutic strategy for breast cancer.
|
30613263 |
2018 |
|
Mammary Neoplasms
|
0.380 |
AlteredExpression
|
group |
BEFREE |
Here we show that miR-200c expression inversely correlates with miR-200c/miR-141 locus methylation in triple-negative breast tumors (TNBC).
|
27717206 |
2017 |
|
Mammary Neoplasms
|
0.380 |
AlteredExpression
|
group |
BEFREE |
In formalin-fixed, paraffin-embedded tissues, these miRNAs were differentially expressed between primary breast tumors and noncancerous breast tissues. miR-21 (P < 0.001) and miR-146a (P = 0.001) were overexpressed, whereas miR-200c (P = 0.004) and miR-210 (P = 0.002) were underexpressed.
|
27197674 |
2016 |
|
Mammary Neoplasms
|
0.380 |
Biomarker
|
group |
BEFREE |
Analysis of a publicly available gene expression dataset for 100 breast tumors revealed a statistically significant negative correlation between ADAM12-L and both miR-29b and miR-200c.
|
25886595 |
2015 |
|
Mammary Neoplasms
|
0.380 |
Biomarker
|
group |
BEFREE |
Since survival upon detachment from basement membrane is required for metastasis, the ability to resist anoikis contributes to the metastatic potential of breast tumors. miR-200c, a potent repressor of epithelial to mesenchymal transition, is expressed in luminal breast cancers, but is lost in more aggressive basal-like, or triple negative breast cancers (TNBC).
|
23185507 |
2012 |
|
Mammary Neoplasms
|
0.380 |
AlteredExpression
|
group |
BEFREE |
Furthermore, loss of p53 correlates with a decrease in the level of miR-200c, but an increase in the expression of EMT and stemness markers, and development of a high tumour grade in a cohort of breast tumours.
|
21336307 |
2011 |
|
Mammary Neoplasms
|
0.380 |
Biomarker
|
group |
CTD_human |
Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin.
|
20099276 |
2010 |
|
Mammary Neoplasms
|
0.380 |
Therapeutic
|
group |
CTD_human |
E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells.
|
19839049 |
2010 |
|
Mammary Neoplasms
|
0.380 |
Therapeutic
|
group |
CTD_human |
Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin.
|
20099276 |
2010 |
|
Mammary Neoplasms
|
0.380 |
Biomarker
|
group |
CTD_human |
E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells.
|
19839049 |
2010 |