Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-21 expression was decreased in sepsis patients compared with HCs, and further receiver operating characteristic (ROC) curve analysis revealed that miR-21 was of a good value in predicting sepsis risk (area under the curve [AUC]: 0.801, 95% CI: 0.758-0.844).
|
31778243 |
2020 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> This study demonstrates a critical role for exosomal miR-21 in renoprotection conferred by limb rIPC against sepsis and suggests that rIPC and exosomes might serve as the possible therapeutic strategies for sepsis-induced kidney injury.
|
30809283 |
2019 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results demonstrate that S100A9 promotes MDSC expansion and immunosuppression in late/chronic sepsis by inducing the expression of miR-21 and miR-181b.
|
31078118 |
2019 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The T allele of the miR-21 SNP rs13137 and the T allele of the miR-145 SNP rs353291 (OR = 0.685, 95% CI = 0.566-0.820, P < .001) were found to be a protective factor for sepsis (OR = 0.755, 95% CI = 0.632-0.896, P < .001).
|
31415369 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results support a myeloid cell loop in which NFI-A and miR-21 and miR-181b sustain Gr1<sup>+</sup>CD11b<sup>+</sup> MDSC-dependent immunosuppression during sepsis.
|
29172874 |
2018 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-21 is required for local and remote ischemic preconditioning in multiple organ protection against sepsis, and up-regulation of miR-21 may be a potential therapy for sepsis.
|
28437377 |
2017 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, transcription factor Rb phosphorylation supports Stat3 and C/EBPβ accumulation at both miRNA promoters, and C/EBPβ or Stat3 depletion by siRNA in sepsis Gr1<sup>+</sup>CD11b<sup>+</sup> MDSCs inhibits miR-21 and miR-181b expression.
|
27430527 |
2017 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results were shown that miRNA-21 over-expression had effects to protect kidney cell apoptosis induced by sepsis via PTEN/PI3K/AKT signaling pathway.
|
28821165 |
2017 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MiR-128 level was decreased and miR-21 level was increased in podocytes in vitro and in the sepsis patient.
|
28497421 |
2017 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Surprisingly, we find that intracellular S100A9 protein translocates from the cytosol to nucleus in Gr1<sup>+</sup>CD11b<sup>+</sup> MDSCs during late sepsis and promotes expression of miR-21 and miR-181b immune repressor mediators.
|
29204146 |
2017 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, pretreatment of JAK2 overexpressing vector could abolish the effects of miR-375 on miR-21 level and the amount of sepsis Gr1+CD11b+ MDSCs.
|
28006751 |
2017 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, by stimulating proinflammatory PDCD4 and decreasing the abundance of miR-21, decorin signaling boosts inflammatory activity in sepsis and suppresses tumor growth.
|
22087031 |
2011 |