MIR21, microRNA 21, 406991

N. diseases: 726; N. variants: 2
Disease: Knee pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0231749
Disease: Knee pain
Knee pain 		0.010 Biomarker phenotype BEFREE A single intra-articular injection of miR-21 inhibitor exerted long-term analgesia of knee OA pain, whereas miR-21 injection in naive rats caused knee joint pain. miR-21 mutant, which lacks the Toll-like receptor (TLR) binding motif, but not in the seed sequence, did not cause joint pain, suggesting a non-canonical mode of action different from translational repression. 31841992 2020