|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study aims to investigate the tumor suppressive effects of TROP-2 in cervical cancer cells and to explain the underlying mechanisms.
|
30429055 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, Trop2-IgG exerted critical tumor inhibitory effects in OC xenografts.
|
30879767 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transfection of short hairpin RNA (shRNA) targeting TROP2 (sh‑TROP2) reduced cell proliferation, migration and invasion of OSCC cell lines, whereas overexpression of TROP2 increased proliferation, migration and invasion. sh‑TROP2 transfection in OSCC cell lines inhibited tumor growth in OSCC mouse models.
|
31638186 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Trop-2 is an ideal candidate for targeted therapeutics due to it being a transmembrane protein with an extracellular domain overexpressed on a wide variety of tumors as well as its upregulated expression relative to normal cells.
|
30881031 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Trophoblast cell surface antigen 2 (Trop-2) belongs to the family of tumor-associated calcium signal transducer (<i>TACSTD</i>) and is required for the stability of claudin-7 and claudin-1, which are often dysregulated or lost in carcinogenesis.
|
31177095 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PC and CC xenograft tumor growth was significantly inhibited by TROP2-targeted PIT relative to controls.
|
31674732 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Co-treatment with anti-ErbB3 and anti-Trop2 antibodies is synergistic and produces a greater anti-tumor response than either antibody alone.
|
29305574 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The human trophoblast cell surface antigen 2 (Trop2) belongs to the tumor-associated calcium signal transducer gene family.
|
29901071 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, Trop‑2‑CD40L VLP immunization increased the survival rate of Lewis tumor‑bearing mice more significantly when compared with Trop‑2 only VLPs.
|
29568866 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Further studies are needed to identify biomarkers that indicate how TROP2 signaling affects tumor growth and whether targeting TROP2 would be beneficial to the patient.
|
30002602 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Trop-2 staining of archived tumor specimens, clearance of IMMU-132 and its constituents (ie, immunoglobulin G [IgG], SN-38 [a camptothecin, the active component of irinotecan], and glucuronidated SN-38 [SN-38G]), antibody responses, and uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) levels were determined.
|
28558150 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
By flow cytometry, both normal and tumor CR cells expressed basal, luminal, and stem cell markers, with the majority of the normal and tumor CR cells expressing prostate basal cell markers, CD44 and Trop2, as well as luminal marker, CD13, suggesting a transit-amplifying phenotype.
|
28009986 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Trop2+/AREG+ protein coexpression were associated with Tumor Node Metastasis (TNM) stage (χ<sup>2</sup> = 50.345, P < 0.001), tumor size (χ<sup>2</sup> = 40.349, P < 0.001), lymph node metastases (χ<sup>2</sup> = 26.481, P < 0.001), and distant metastases (χ<sup>2</sup> = 8.387, P = 0.039).
|
28256068 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, gallbladder cancer cells with TROP2 knockdown formed smaller xenografted tumors in vivo.
|
28423362 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Association of tumor TROP2 expression with prognosis varies among lung cancer subtypes.
|
28404926 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
More than 90% of 26 assessable archival tumor specimens were highly positive (2+, 3+) for Trop-2 by immunohistochemistry, which suggests that Trop-2 is not a predictive biomarker for response.
|
28548889 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Trophoblast cell surface antigen 2 (TROP2) or tumor-associated calcium signal transducer 2 (TACSTD2) is a 36-kDa type I transmembrane glycoprotein and exerts dual functions as an oncogene and tumor suppressor in cancer cells.
|
26626643 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lentiviral downregulation of endogenous Trop-2 abolished tumor response to AKT blockade, indicating Trop-2 as a mandatory activator of AKT.
|
27022065 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the subgroup analysis revealed that the associations between TROP2 overexpression and the outcome endpoints (OS or DFS) were significant in in patients with female genital system neoplasms, as well in gastrointestine neoplasms.
|
27645103 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Single-dose administration of RN927C at 0.75 to 3 mg/kg was generally sufficient to induce sustained regression of Trop-2-expressing tumors and showed superior efficacy over standard treatment with paclitaxel or gemcitabine.
|
27582525 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased Trop2 protein levels in GC were associated with increased differentiation, tumor node metastasis stage, tumor size, lymph node metastasis, distant metastasis, and H. pylori infection.
|
26716416 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although Trop2 expression is sufficient to promote tumour growth, the surprising discovery that Trop2-null mice have an increased risk of tumour development has highlighted the complexity of Trop2 signaling.
|
25523132 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Enhanced Delivery of SN-38 to Human Tumor Xenografts with an Anti-Trop-2-SN-38 Antibody Conjugate (Sacituzumab Govitecan).
|
26106073 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In primary HNSCC, detection of ErbB3 activation was limited to Trop2 negative tumors.
|
25238142 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Trop2 plays an important role in proliferation and invasion of tumors.
|
24816726 |
2014 |