Cholestasis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Plasma microRNA profiles in rat models of hepatocellular injury, cholestasis, and steatosis.
|
22363424 |
2012 |
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
MicroRNA-24-3p regulates Hodgkin's lymphoma cell proliferation, migration and invasion by targeting DEDD.
|
30655776 |
2019 |
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
MicroRNA-24 aggravates atherosclerosis by inhibiting selective lipid uptake from HDL cholesterol via the post-transcriptional repression of scavenger receptor class B type I.
|
29407889 |
2018 |
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
MicroRNA-24 inhibits the proliferation and migration of endothelial cells in patients with atherosclerosis by targeting importin-α3 and regulating inflammatory responses.
|
29250154 |
2018 |
Atherosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
MicroRNA-24 inhibits the proliferation and migration of endothelial cells in patients with atherosclerosis by targeting importin-α3 and regulating inflammatory responses.
|
29250154 |
2018 |
Atherosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
MicroRNA-24 aggravates atherosclerosis by inhibiting selective lipid uptake from HDL cholesterol via the post-transcriptional repression of scavenger receptor class B type I.
|
29407889 |
2018 |
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Collectively, these results suggested that as a tumor suppressor, miR-24-1 may regulate mouse hepatocarcinoma cells migration and invasion, at least partially through targeting OGT, which could regulate the O-GlcNAcylation and the stability of this oncoprotein c-Myc.
|
28499244 |
2017 |
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
The present study revealed that miRNA-24 down-regulates p53 through binding to the 3'-UTR of p53 mRNA based on a luciferase reporter assay, and that the expression level of miR-24 could affect the invasion of HCC lines via p53.
|
27780140 |
2016 |
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
MicroRNA-24 regulates macrophage behavior and retards atherosclerosis.
|
24990232 |
2014 |
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our findings show a novel mechanism by which miR-24 promotes hepatic lipid accumulation and hyperlipidemia by repressing Insig1, and suggest the use of miR-24 inhibitor as a potential therapeutic agent for NAFLD and/or atherosclerosis.
|
24677249 |
2014 |
Atherosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
MicroRNA-24 regulates macrophage behavior and retards atherosclerosis.
|
24990232 |
2014 |
Atherosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our findings show a novel mechanism by which miR-24 promotes hepatic lipid accumulation and hyperlipidemia by repressing Insig1, and suggest the use of miR-24 inhibitor as a potential therapeutic agent for NAFLD and/or atherosclerosis.
|
24677249 |
2014 |
Tumor Cell Invasion
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Silencing microRNA-24 in macrophage CSF macrophages significantly increased MMP-14 expression and enhanced their invasive capacity, mimicking granulocyte/macrophage CSF macrophages, and suggesting that granulocyte/macrophage CSF modulates MMP-14 protein expression and subsequent macrophage invasion in a microRNA-24-dependent manner.
|
24990232 |
2014 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Compared with lung carcinoma patients with Grade I-II and tumor size smaller than 3 cm, upregulated miR-24 expression was observed in those with Grade III-IV and tumor size larger than 3 cm.
|
30402849 |
2018 |
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, these results suggested that as a tumor suppressor, miR-24-1 may regulate mouse hepatocarcinoma cells migration and invasion, at least partially through targeting OGT, which could regulate the O-GlcNAcylation and the stability of this oncoprotein c-Myc.
|
28499244 |
2017 |
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Therefore, miR-24 may be a potential therapeutic target for treatment of HCC.
|
27780140 |
2016 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
We found that miR-24 was upregulated in HCC tumor tissues relative to adjacent noncancerous tissue samples, and that the high expression of miR-24 was significantly correlated with larger tumor size, higher microvessel density, and tumor dedifferentiation.
|
24800232 |
2014 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Here, we found that microRNA-24-1 (miR-24-1) is significantly reduced in bladder cancer (BC) tissues, suggesting that it functions as a tumour suppressor.
|
24999187 |
2014 |
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These results indicate for the first time that miR-24 may modify AFB1-related HCC prognosis and tumorigenesis.
|
24800232 |
2014 |
Anaplasia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results demonstrated that the elevated miR-24, to the utmost extent, preserves beta cell mass by inhibiting apoptosis and inducing dedifferentiation.
|
30753517 |
2019 |
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
This study not only provides a novel mechanism by which miR-24 dominates beta cell turnover under persistent metabolic stress but also offers a therapeutic consideration for treating diabetes by inducing dedifferentiated beta cells to re-differentiation.
|
30753517 |
2019 |
Heart failure
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Subsequent gene/ncRNA expression analysis was assessed using quantitative reverse transcription polymerase chain reaction and revealed 6 genes: 4 hypermethylated ( HEY2, MSR1, MYOM3, and COX17), 2 hypomethylated ( CTGF and MMP2); and 2 microRNA: 1 hypermethylated (miR-24-1), 1 hypomethylated (miR-155) with significantly upregulated or downregulated expression levels consistent with the direction of methylation in the particular HF subgroup.
|
30798618 |
2019 |
Congestive heart failure
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Subsequent gene/ncRNA expression analysis was assessed using quantitative reverse transcription polymerase chain reaction and revealed 6 genes: 4 hypermethylated ( HEY2, MSR1, MYOM3, and COX17), 2 hypomethylated ( CTGF and MMP2); and 2 microRNA: 1 hypermethylated (miR-24-1), 1 hypomethylated (miR-155) with significantly upregulated or downregulated expression levels consistent with the direction of methylation in the particular HF subgroup.
|
30798618 |
2019 |
Heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Prolonged cardiac hypertrophy may lead to heart failure, but little is known about the role of miR-24 in cardiac hypertrophy.
|
29786048 |
2018 |
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Prolonged cardiac hypertrophy may lead to heart failure, but little is known about the role of miR-24 in cardiac hypertrophy.
|
29786048 |
2018 |