Osteosarcoma of bone
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study aims to discuss the effects of miR-27a and its target gene secreted frizzled related protein 1 (<i>SFRP1</i>) on proliferation and invasion of human osteosarcoma cells via Wnt/β-catenin signaling pathway.
|
31072914 |
2019 |
Osteosarcoma of bone
|
0.100 |
Biomarker
|
disease |
BEFREE |
As a result, the miRNA-TF-mRNA regulatory network, including 1049 nodes (516 miRNA, 25 TFs, and 508 DEGs) and 15942 edges (interaction relationships, such as Pparg-Abca1 and miR-590-3p-AXIN2), was constructed, from which three significant modules were extracted and modules 2 and 3 contained interactions between miRNAs/TFs and DEGs such as miR-103-3p-<i>AXIN2</i>, miR-124-3p-<i>AR</i>-<i>Tgfb1i1</i>, and miR-27a-3p-<i>PPARG</i>-<i>Abca1</i>. miR-27a-3p was a known miRNA associated with OS.
|
31536386 |
2019 |
Osteosarcoma of bone
|
0.100 |
Biomarker
|
disease |
BEFREE |
Luciferase reporter assays confirmed that CCNG1 is a direct target of miR-27a in osteosarcoma cells.
|
29399167 |
2018 |
Osteosarcoma of bone
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of miR-27-3p significantly accelerated osteosarcoma cell growth via promoting G1-S transition.
|
29494959 |
2018 |
Osteosarcoma of bone
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to explore the role of miR‑27a‑3p in the development and progression of osteosarcoma, the expression of miR‑27a‑3p was inhibited by transfection of the MG-63 cells with miR‑27a‑3p inhibitor.
|
29484426 |
2018 |
Osteosarcoma of bone
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In total, 761 overlapping genes in 987 CNV regions and in the genes in 7,313 miRNA-gene pairs were obtained. miRNAs (hsa-miR-27a-3p, hsa-miR-124-3p, hsa-miR-9-5p, hsa-miR-182-5p, hsa-miR-26a-5p) and the genes [Fibroblast growth factor receptor substrate 2 (<i>FRS2</i>), coronin 1C (<i>CORO1C</i>), forkhead box P1 (<i>FOXP1</i>), cytoplasmic polyadenylation element binding protein 4 (<i>CPEB4</i>) and glucocorticoid induced 1 (<i>GLCCI1</i>)] with the highest degrees of association with osteosarcoma development were identified.
|
29098032 |
2017 |
Osteosarcoma of bone
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings establish that miR-27a/miR-27a* pair plays a significant role in OS metastasis and proposes it as a potential diagnostic and therapeutic target in managing OS metastases.
|
25749032 |
2015 |
Osteosarcoma of bone
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Then, high miR-27a expression was more frequently occurred in osteosarcoma patients with advanced clinical stage (P=0.001), positive distant metastasis (P=0.01) and poor response to chemotherapy (P=0.008).
|
25960240 |
2015 |
Osteosarcoma of bone
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, the expression of miR-26a and miR-27a in osteosarcoma need further investigation in clinical samples.
|
26377680 |
2015 |
Osteosarcoma of bone
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study thus addressed the miR-27a sensitive mechanisms in osteosarcoma.
|
24556602 |
2014 |
Osteosarcoma of bone
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vitro and in vivo functional validation in osteosarcoma cell lines confirmed the tumor suppressive role of miR-16 and the pro-metastatic role of miR-27a.
|
22350417 |
2012 |