MIR27B, microRNA 27b, 407019
N. diseases: 141; N. variants: 0
Source: ALL
Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.070 | AlteredExpression | phenotype | BEFREE | In addition, down-regulation of miR-27b enhanced GES-1 cells' proliferation and metastasis in vitro. | 27844448 | 2017 | ||||
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0.070 | AlteredExpression | phenotype | BEFREE | High pre-operative levels of miR-27b were linked with node metastasis (p = 0.04). | 28058628 | 2017 | ||||
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0.070 | Biomarker | phenotype | BEFREE | More and more studies indicate that microRNA-27b is involved in affecting various biological processes, such as angiogenesis, proliferation, metastasis, and drug resistance, and thus may act as a promising therapeutic target in human cancers. | 28351320 | 2017 | ||||
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0.070 | Biomarker | phenotype | BEFREE | In this study, we aimed to investigate novel miR-27b-mediated targets or signaling pathways associated with the tumorigenesis and metastasis of NSCLC. | 28081743 | 2017 | ||||
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0.070 | Biomarker | phenotype | BEFREE | The identification of novel molecular pathways regulated by miR-23b and miR-27b may lead to a better understanding of the oncogenesis and metastasis of this disease. | 27573718 | 2016 | ||||
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0.070 | Biomarker | phenotype | BEFREE | More importantly, reduction in miR98 and miR27b enhances the epithelial-mesenchymal transition (EMT) of breast cancer cells, and thus promotes breast cancer metastasis. | 26244871 | 2015 | ||||
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0.070 | Biomarker | phenotype | BEFREE | Immunoblotting and TMA-IHC analyses revealed alterations in the expression/phosphorylation of metastamiRs' targets, including ADAMTS-1, AKT1/2/3, ASK1, AURKβ, Birc1, Birc2, Bric5, β-CATENIN, CASP8, CD54, CDK4, CREB, CTGF, CXCR4, CYCLIN-D1, EGFR, ELK1, ESR1, CFOS, FOSB, FRA, GRB10, GSK3β, IL1α, JUND, kRAS, KRTAP1, MCP1, MEGF10, MMP2, MMP3, MMP9, MMP10, MTA2, MYB, cMYC, NF2, NOS3, P21, pP38, PTPN3, CLEAVED PARP, PKC, SDF-1β, SEMA3D, SELE, STAT3, TLR3, TNFα, TNFR1, and VEGF in aggressive cells ex vivo and in a manifold of metastatic tumors in vivo. miRNA mimic (hsa-miR-125b, hsa-miR-27b, hsa-miR-93, hsa-miR-20a) and inhibitor (hsa-miR-1224-3p, hsa-miR-1260) approach for select miRNAs revealed the direct influence of the altered metastamiRs in the regulation of identified protein targets. | 26148557 | 2015 |