Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The examination of liver cancer specimens demonstrated that HBx and TGF-β1 expression was positively correlated with epithelial cell adhesion molecule (EpCAM) and cluster of differentiation 90 (CD90).
|
31740785 |
2020 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When co-cultured immature dendritic cells with EpCAM+ HepG2 cells, 4-AAQB enhanced the expression of MHC class I and II on the surface of liver cancer stem cells and dendritic cells, increased the expression of costimulatory molecules CD80 of dendritic cells and cytokines related to immune activation.
|
30551483 |
2019 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene enrichment analysis indicated that the terms "liver cancer with EPCAM up", "tumor invasiveness up", "methyltransferase complex", and "translational initiation" were enriched in CIMP-H subgroup.
|
31492561 |
2019 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The activation of the Wnt/β-catenin signaling pathway significantly increased the expression of liver cancer stem cells related (LCSCs)-related molecular markers CD90 and EpCAM, which led to the transformation of HPCs into LCSCs.
|
31696964 |
2019 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Exploration of the inter-relationship among liver cancer stem cell markers showed two distinct major cell populations according to EPCAM expression, and the EPCAM<sup>+</sup> cells had upregulated expression of multiple oncogenes.
|
31195060 |
2019 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because EpCAM are overexpressed in multiple carcinomas, including liver cancer, these aptamer-conjugated AIE MSHNs are therefore good candidates for targeted cellular imaging applications.
|
31348641 |
2019 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, immunohistochemistry demonstrates that EpCAM is highly expressed in 80% of H-ChC, implying the stemness of such liver cancer.
|
29497050 |
2018 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Epithelial cell adhesion molecule (EpCAM) is expressed in hepatic progenitor cells and hepatocellular carcinoma (HCC), and is considered a marker of liver cancer stem cells.
|
29970536 |
2018 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Epithelial cell adhesion molecule (EpCAM) is over-expressed in most solid tumors and it has been identified to be a cancer stem cell surface marker in liver cancer.
|
28522194 |
2017 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EpCAM+ Liver Cancer Stem-Like Cells Exhibiting Autocrine Wnt Signaling Potentially Originate in Cirrhotic Patients.
|
28176469 |
2017 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment with either suberohydroxamic acid or AG-014699 reduced the number of EpCAM(+) liver cancer stem cells in vitro, and suberohydroxamic acid and AG-014699 in combination successfully inhibited tumor growth in a mouse xenograft model.
|
26095183 |
2015 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The EpCAM(+) cells were sorted out from unfractionated fetal liver cells and liver cancer cells using the FACS analysis and miRNA expression profiles of two groups were screened through microarray platform.
|
23936298 |
2013 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
E-cadherin is an epithelial cell adhesion molecule, and decreased E-cadherin expression in liver cancer is associated with poor prognosis.
|
17548247 |
2007 |