|
Malignant neoplasm of lung
|
0.340 |
Biomarker
|
disease |
BEFREE |
The results indicated that the CD133 immune PLGA magnetic beads (with diameter 356.25 ± 0.64 nm) can effectively separate more lung cancer stem cells under the serum-free suspension culture compared with MACS CD133 MicroBead Kit.
|
29843871 |
2018 |
|
Malignant neoplasm of lung
|
0.340 |
Biomarker
|
disease |
CTD_human |
Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.
|
27935865 |
2017 |
|
Malignant neoplasm of lung
|
0.340 |
Biomarker
|
disease |
BEFREE |
Culturing A549, H1792 and H1975 lung cancer cell lines with the MARCKS ED peptide led to reduced levels of phosphorylated MARCKS and phosphorylated Akt serine/threonine kinase 1.
|
28454237 |
2017 |
|
Malignant neoplasm of lung
|
0.340 |
Biomarker
|
disease |
BEFREE |
To study the importance of MARCKS in lung cancer biology, we used inducible overexpression of wild-type (WT) and non-phosphorylatable (NP)-MARCKS in A549 lung cancer cells that had a low level of endogenous MARCKS.
|
25524703 |
2015 |
|
Malignant neoplasm of lung
|
0.340 |
Biomarker
|
disease |
BEFREE |
These results indicate a crucial role for MARCKS, specifically its phosphorylated form, in potentiating lung cancer cell migration/metastasis and suggest a potential use of MARCKS-related peptides in the treatment of lung cancer metastasis.
|
23955080 |
2014 |
|
Lung Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.
|
27935865 |
2017 |
|
Lung Neoplasms
|
0.310 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemistry scoring of MARCKS protein expression in a diverse lung tumor tissue array revealed that the majority of squamous cell carcinomas stained positive for MARCKS while other histologies, such as adenocarcinomas, had lower levels.
|
25524703 |
2015 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration.
|
19192274 |
2009 |
|
Adenoid Cystic Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma.
|
16762588 |
2006 |
|
Salivary Gland Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma.
|
16762588 |
2006 |
|
Malignant neoplasm of salivary gland
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genes associated with early development, apoptosis and cell cycle regulation define a gene expression profile of adenoid cystic carcinoma.
|
16762588 |
2006 |
|
Visual seizure
|
0.200 |
Biomarker
|
disease |
RGD |
Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization.
|
11054811 |
2000 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Myristoylated alanine‑rich C‑kinase substrate (MARCKS) serves an important role in various pathological processes in several malignancies.
|
30816497 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The MARCKS-ED-photodoxaz system targeting exosomes and utilizing photochemistry will potentially provide a new approach for the treatment of cancer, especially for highly progressive and invasive metastatic cancers.
|
30703330 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressive functions of BASP1 and MARCKS could be exploited to expand the spectrum of future innovative therapeutic approaches to inhibit growth and viability of susceptible human tumors.
|
31058089 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MARCKS protein expression in tumor and stromal cells was analyzed by immunohistochemistry (IHC) in a retrospective series of 96 pre-chemotherapy MBC samples and 80 normal breast samples, from Tunisian patients treated at Salah Azaiez Institute.
|
31771045 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
RESULTS TCGA analysis and our data suggest that transcript abundance and protein level of MARCKS was higher in GC tumor samples compared with peri-tumor tissues.
|
30623893 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Bone marrow-derived primary MSCs or murine 10 T1/2 MSCs were tumor-conditioned (TC-MSCs) and co-cultured with B16 melanoma antigen-specific DCs and MACS purified CD4<sup>+</sup> and CD8<sup>+</sup> T cells.
|
31547863 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data suggested that miR‑34c‑3p acts as a tumor suppressor via regulation of MARCKS expression in OS progression and miR‑34c‑3p may be a promising therapeutic target for this type of cancer.
|
28075441 |
2017 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We compared MARCKS expression in normal versus cancer samples, and searched for correlations with clinicopathological features, including overall survival (OS).
|
29295532 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We further demonstrated that higher MARCKS expression promotes growth and angiogenesis in vivo in an RCC xenograft tumor.
|
28166200 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor samples showed heterogeneity with respect to MARCKS staining: 18% were scored as MARCKS-positive (stained cells ≥ 1%) and 82% as MARCKS-negative.
|
28009981 |
2017 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MARCKS contributes to stromal cancer-associated fibroblast activation and facilitates ovarian cancer metastasis.
|
27081703 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Suppression of MARCKS resulted in the loss of CAF features, and diminished role of CAFs in supporting tumor cell growth in 3D organotypic cultures and in murine xenograft model.
|
27081703 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This correlation analysis revealed epigenetic regulation of genes known to modulate TP53, WNT, and IGF signaling, as well as silencing of the tumor suppressor MARCKS, previously unreported in ACC.
|
26963385 |
2016 |