|
Idiopathic pulmonary arterial hypertension
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Active RhoA/Rho kinase signaling and decreased nuclear translocation of Smad1 were found in primary cultured PASMCs from the rat model of PAH compared with the control PASMCs.
|
30603049 |
2019 |
|
Idiopathic pulmonary arterial hypertension
|
0.350 |
Biomarker
|
disease |
BEFREE |
These results indicate that ALK-1 and Smad1 participate in the formation of PAH and the process of PVR, and suggest that NAC may inhibit PAH by inhibiting the expression of ALK-1 and Smad1 in the pulmonary artery.
|
29904431 |
2018 |
|
Idiopathic pulmonary arterial hypertension
|
0.350 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
|
29650961 |
2018 |
|
Idiopathic pulmonary arterial hypertension
|
0.350 |
Biomarker
|
disease |
BEFREE |
These results indicate that the therapeutic effect of BMPR2 gene delivery on PAH is associated with a switch between TGF-β-Smad2/3 signalling to BMPR2-Smad1/5/8 signalling.
|
26809239 |
2016 |
|
Idiopathic pulmonary arterial hypertension
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
In the monocrotaline rat model of PAH, which is characterized by BMPR-II deficiency, sildenafil prevented the development of pulmonary hypertension and vascular remodeling, and partly restored Smad1/5 phosphorylation and Inhibitor of DNA binding protein 1 gene expression in vivo in monocrotaline exposed rat lungs.
|
23139294 |
2013 |
|
Idiopathic pulmonary arterial hypertension
|
0.350 |
Biomarker
|
disease |
BEFREE |
In the monocrotaline rat model of PAH, associated with reduced BMPR-II expression, we confirmed that treprostinil inhibited smooth muscle cell proliferation and prevented progression of PAH while enhancing Smad1/5 phosphorylation and Id1 gene expression.
|
20522807 |
2010 |
|
Cocaine Abuse
|
0.300 |
Biomarker
|
disease |
CTD_human |
E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking.
|
30158054 |
2018 |
|
Substance Withdrawal Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking.
|
30158054 |
2018 |
|
Drug Withdrawal Symptoms
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking.
|
30158054 |
2018 |
|
Withdrawal Symptoms
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking.
|
30158054 |
2018 |
|
Idiopathic pulmonary hypertension
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
|
29650961 |
2018 |
|
Cocaine-Related Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking.
|
30158054 |
2018 |
|
Familial primary pulmonary hypertension
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
|
29650961 |
2018 |
|
Cocaine Dependence
|
0.300 |
Biomarker
|
disease |
CTD_human |
E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking.
|
30158054 |
2018 |
|
2-oxo-hept-3-ene-1,7-dioate hydratase activity
|
0.300 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
|
29650961 |
2018 |
|
Pulmonary Hypertension
|
0.200 |
Biomarker
|
phenotype |
RGD |
Smad signaling in the rat model of monocrotaline pulmonary hypertension.
|
18367643 |
2008 |
|
Pulmonary Hypertension
|
0.200 |
Biomarker
|
phenotype |
RGD |
Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension.
|
17347486 |
2007 |
|
Nephrotic Syndrome
|
0.200 |
Biomarker
|
group |
RGD |
Chinese herbal formula Qilong-Lishui granule improves puromycin aminonucleoside-induced renal injury through regulation of bone morphogenetic proteins.
|
17803470 |
2007 |
|
Diabetes Mellitus, Experimental
|
0.200 |
ModifyingMutation
|
disease |
RGD |
Expression of Smad1 is directly associated with mesangial matrix expansion in rat diabetic nephropathy.
|
16482100 |
2006 |
|
Liver Cirrhosis, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells.
|
16447265 |
2006 |
|
Glomerulonephritis
|
0.200 |
Biomarker
|
disease |
RGD |
These data suggest that the activation of STAT3 and Smad1 participates in the developing process of glomerulosclerosis in experimental glomerulonephritis.
|
15591053 |
2005 |
|
Male infertility
|
0.200 |
Biomarker
|
phenotype |
RGD |
To study the expression of Smad1 and Smad5 in the testis of infertile rats with adenine-modeled kidney-yang deficiency and the pathological mechanism of infertility with kidney-yang deficiency, attempting to obtain experimental evidence for the prevention and treatment of male infertility.
|
15704675 |
2005 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
We further show that DAC restores SMAD1 expression and reduces the tumor burden in a novel patient-derived orthotopic xenograft model.
|
31648327 |
2019 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemistry (IHC) was utilized to assess the CD105 expression in tumor tissue, and real-time quantitative PCR (qPCR) was used to determine the mRNA expression of CD105 of monocytes in tumor tissue and PB, as well as the mRNA expression of TGFβ1, Smad1-4 in tumor tissue.
|
29799303 |
2018 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
AA treatment increased the expression of SMAD1, a tumor suppressor gene known to be suppressed by methylation, and increased chemosensitivity of lymphoma cells.
|
28731456 |
2017 |