SMAD2, SMAD family member 2, 4087

N. diseases: 289; N. variants: 8
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.300 AlteredExpression disease BEFREE In addition, 3 of 10 human HCC tissues showed nuclear localization of Smad 2 and low mRNA levels of p15INK4B and antagonistic Smads but a high level of PAI-1. 10728705 2000
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.300 GeneticVariation disease BEFREE These results suggest that mutations of the TGFbetaRII, Smad2, and Smad4 genes are rare, and that genetic instability is uncommon in human hepatocellular carcinoma. 9863018 1999
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.300 GeneticVariation disease BEFREE We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. 10490821 1999