SMAD3, SMAD family member 3, 4088

N. diseases: 470; N. variants: 95
Disease: Malignant tumor of colon ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.160 Biomarker disease BEFREE Moreover, we found that Smad4 combined with Smad3 can positively regulate VEGF-C during colon cancer metastasis through binding to VEGF-C gene promoter. 31739210 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.160 GeneticVariation disease GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.160 GeneticVariation disease BEFREE In addition, the overexpression pattern of COX-2 in Smad3 mutant mice that develop colon cancer was identified. 28454287 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.160 AlteredExpression disease BEFREE Importantly, we also demonstrated that Smad4 could increase the phosphorylation level of Smad3, but not Smad2, which may be one of the mechanisms underlying these effects of Smad4 in colon cancer. 28445620 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.160 GeneticVariation disease BEFREE Fifteen genes (DUSP2, INFGR1, IL6, IRF2, JAK2, MAP3K10, MMP1, NFkB1A, NOS2A, PIK3CA, SEPX1, SMAD3, TLR2, TYK2, and VDR) were associated with colon cancer mortality (PARTP < 0.05); JAK2 (PARTP  = 0.0086), PIK3CA (PARTP = 0.0098), and SMAD3 (PARTP = 0.0059) had the strongest associations. 25541970 2014
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.160 Biomarker disease BEFREE Previous studies have shown a requirement for a bacterial trigger for the colitis and colon cancer phenotype in Smad3(-/-) mice. 24244446 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.160 GeneticVariation disease BEFREE Likewise, 1 of 3 tagSNPs for TGFβR1, 2 of the 4 tagSNPs for Smad2, and 4 of 37 Smad3 tagSNPs were associated with colon cancer. 21068203 2011