SMAD3, SMAD family member 3, 4088

N. diseases: 470; N. variants: 95
Disease: Choriocarcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008497
Disease: Choriocarcinoma
Choriocarcinoma 		0.030 Biomarker disease BEFREE To test whether Smad3 restitution restores TGF-beta response in choriocarcinoma cells, we produced a Smad3-expressing cell line (JAR-smad3/c). 12504095 2003
CUI: C0008497
Disease: Choriocarcinoma
Choriocarcinoma 		0.030 AlteredExpression disease BEFREE Restoration of TGF-beta regulation of plasminogen activator inhibitor-1 in Smad3-restituted human choriocarcinoma cells. 12074587 2002
CUI: C0008497
Disease: Choriocarcinoma
Choriocarcinoma 		0.030 Biomarker disease BEFREE These results suggest that loss of smad3 may account for a functional disruption in the TGF-beta signaling pathway in choriocarcinomas, but not in the premalignant trophoblast. 11549251 2001