SMAD3, SMAD family member 3, 4088

N. diseases: 470; N. variants: 95
Disease: Coronary heart disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease BEFREE Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk. 30307970 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease BEFREE The coronary artery disease-associated rs17293632C>T single nucleotide polymorphism represents a novel functional cis-acting element at the SMAD3 locus. 26966274 2016
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease BEFREE The aim of this work was to find evidence on whether SMAD3 variations might be associated with ventricular septal defects (VSD) or other congenital heart diseases (CHD). 26110764 2015
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease BEFREE The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured. 21804106 2012
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease GWASDB Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. 21347282 2011
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease GWASCAT Genomewide association analysis of coronary artery disease. 17634449 2007
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.140 GeneticVariation disease GWASDB Genomewide association analysis of coronary artery disease. 17634449 2007