SMAD3, SMAD family member 3, 4088

N. diseases: 470; N. variants: 95
Disease: Coronary Artery Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.130 AlteredExpression disease BEFREE HCASMC phenotype, and gene expression patterns promoted by SMAD3 were noted to have opposing direction of effect compared to another CAD associated TF, TCF21. 30307970 2018
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.130 GeneticVariation disease GWASCAT Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease. 29212778 2018
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.130 GeneticVariation disease GWASCAT Association analyses based on false discovery rate implicate new loci for coronary artery disease. 28714975 2017
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.130 GeneticVariation disease BEFREE The coronary artery disease-associated rs17293632C>T single nucleotide polymorphism represents a novel functional cis-acting element at the SMAD3 locus. 26966274 2016
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.130 GeneticVariation disease GWASCAT A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. 26343387 2015
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.130 GeneticVariation disease BEFREE Moreover, for some hub genes (such as SMAD3) that were susceptible to both T2D and CAD, their associated polymorphisms were unique to each of the two diseases. 24508273 2014